Abstract

Background

Recurrent wheeze and asthma in childhood are commons causes of chronic respiratory morbidity globally. We aimed to explore the association between respiratory syncytial virus (RSV) infection in early life and subsequent respiratory sequelae up to age 12 years.

Methods

We estimated the strength of association by 3 control groups and 3 follow-up age groups, with data from studies published between January 1995 and May 2018. We also estimated associations by diagnostic criteria, age at infection, and high-risk population.

Results

Overall, we included 41 studies. A statistically significant association was observed between early life RSV infection and subsequent childhood recurrent wheeze, in comparison to those who were healthy or those without respiratory symptoms: OR 3.05 (95% confidence interval [CI], 2.50–3.71) for 0 to <36 months follow-up age; OR 2.60 (95% CI, 1.67–4.04) for 36–72 months; and OR 2.14 (95% CI, 1.33–3.45) for 73–144 months. For the subsequent development of asthma, a statistically significant association was observed only in relation to those aged 73–144 months at follow-up: OR 2.95 (95% CI, 1.96–4.46).

Conclusions

Further studies using standardized definitions and from diverse settings are needed to elucidate the role of confounders and provide more robust estimates.

中文翻译：

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生命早期与呼吸道合胞病毒相关的急性下呼吸道感染与小儿复发性喘息和哮喘之间的关联

抽象的

背景

儿童反复发作的喘息和哮喘是全球范围内慢性呼吸道疾病的常见原因。我们旨在探讨早期呼吸道合胞病毒（RSV）感染与直至12岁的后续呼吸道后遗症之间的关系。

方法

我们通过1995年1月至2018年5月发表的研究数据，估计了3个对照组和3个随访年龄组的关联强度。我们还通过诊断标准，感染年龄和高危人群来评估关联。

结果

总体而言，我们纳入了41项研究。与健康者或无呼吸道症状的人相比，早期RSV感染和随后的儿童反复性喘息之间存在统计学意义的关联：OR为3.05（95％置信区间[CI]，2.50-3.71），0至<36几个月的随访年龄；或2.60（95％CI，1.67–4.04）为36–72个月；以及73-144个月的OR为2.14（95％CI，1.33-3.45）。对于随后的哮喘发作，仅在随访中观察到与年龄在73-144个月之间的患者有统计学意义的相关性：OR 2.95（95％CI，1.96-4.46）。

结论

需要使用标准化定义和来自不同背景的进一步研究来阐明混杂因素的作用并提供更可靠的估计。