Chromosomal translocation leads to the juxtaposition of two otherwise separate DNA loci, which could result in gene fusion. These rearrangements at the DNA level are catastrophic events and often have causal roles in tumorigenesis. The oncogenic DNA messages are transferred to RNA molecules, which are in most cases translated into cancerous fusion proteins. Gene expression programs and signaling pathways are altered in these cytogenetically abnormal contexts. Notably, non-coding RNAs have attracted increasing attention and are believed to be tightly associated with chromosome-rearranged cancers. These RNAs not only function as modulators in downstream pathways but also directly affect chromosomal translocation or the associated products. This review summarizes recent research advances on the relationship between non-coding RNAs and chromosomal translocations and on diverse functions of non-coding RNAs in cancers with chromosomal rearrangements.

中文翻译：

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具有染色体重排的癌症中的非编码RNA：特征，原因，功能和含义。

染色体易位导致两个原本分开的DNA基因座并置，这可能导致基因融合。在DNA水平上的这些重排是灾难性事件，通常在肿瘤发生中起因果作用。致癌的DNA信息被转移到RNA分子，在大多数情况下，RNA分子被翻译成癌性融合蛋白。在这些细胞遗传学异常情况下，基因表达程序和信号通路被改变。值得注意的是，非编码RNA引起了越来越多的关注，并被认为与染色体重排的癌症紧密相关。这些RNA不仅在下游途径中起调节剂的作用，而且还直接影响染色体易位或相关产物。