A phenomenon in schizophrenia patients that deserves attention is the high comorbidity rate with obsessive-compulsive disorder (OCD). Little is known about the neurobiological basis of schizo-obsessive comorbidity (SOC). We aimed to investigate whether specific changes in white matter exist in patients with SOC and the relationship between such abnormalities and clinical parameters. Twenty-eight patients with SOC, 28 schizophrenia patients, 30 OCD patients, and 30 demographically matched healthy controls were recruited. Using Tract-based Spatial Statistics and Probabilistic Tractography, we examined the pattern of white matter abnormalities in these participants. We also used ANOVA and Support Vector Classification of various white matter indices and structural connection probability to further examine white matter changes among the 4 groups. We found that patients with SOC had decreased fractional anisotropy (FA) and increased radial diffusivity in the right sagittal stratum and the left crescent of the fornix/stria terminalis compared with healthy controls. We also found changed connection probability in the Default Mode Network, the Subcortical Network, the Attention Network, the Task Control Network, the Visual Network, the Somatosensory Network, and the cerebellum in the SOC group compared with the other 3 groups. The classification results further revealed that FA features could differentiate the SOC group from the other 3 groups with an accuracy of .78. These findings highlight the specific white matter abnormalities found in patients with SOC.

中文翻译：

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通过基于行径的空间统计和概率行列式识别精神分裂症合并症。

精神分裂症患者中值得引起注意的现象是强迫症（OCD）合并症的发生率很高。关于精神分裂症合并症（SOC）的神经生物学基础知之甚少。我们旨在调查SOC患者中白质是否存在特定变化，以及此类异常与临床参数之间的关系。招募了28位SOC患者，28位精神分裂症患者，30位OCD患者和30位人口统计学匹配的健康对照。使用基于行迹的空间统计和概率行迹，我们检查了这些参与者中白质异常的模式。我们还使用了各种白质指数和结构连接概率的ANOVA和支持向量分类，以进一步检查4组之间的白质变化。我们发现，与健康对照组相比，SOC患者的矢状位/纹状体的右矢状层和左新月形的分数各向异性（FA）降低​​，径向扩散性增加。我们还发现，与其他3个组相比，默认模式网络，皮层下网络，注意力网络，任务控制网络，视觉网络，体感网络和小脑的连接概率发生了变化。分类结果进一步表明，FA特征可以将SOC组与其他3个组区分开，准确度为.78。这些发现强调了在SOC患者中发现的特定的白质异常。