Ligand‐Installed Nanocarriers toward Precision Therapy,Advanced Materials

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Ligand‐Installed Nanocarriers toward Precision Therapy
Advanced Materials ( IF 27.4 ) Pub Date : 2019-07-28 , DOI: 10.1002/adma.201902604
Peng Mi ₁ , Horacio Cabral ₂ , Kazunori Kataoka _{3,

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Affiliation

Development of drug‐delivery systems that selectively target neoplastic cells has been a major goal of nanomedicine. One major strategy for achieving this milestone is to install ligands on the surface of nanocarriers to enhance delivery to target tissues, as well as to enhance internalization of nanocarriers by target cells, which improves accuracy, efficacy, and ultimately enhances patient outcomes. Herein, recent advances regarding the development of ligand‐installed nanocarriers are introduced and the effect of their design on biological performance is discussed. Besides academic achievements, progress on ligand‐installed nanocarriers in clinical trials is presented, along with the challenges faced by these formulations. Lastly, the future perspectives of ligand‐installed nanocarriers are discussed, with particular emphasis on their potential for emerging precision therapies.

中文翻译：

配体安装的纳米载体用于精确治疗

选择性靶向肿瘤细胞的药物递送系统的开发一直是纳米医学的主要目标。实现这一里程碑的一种主要策略是将配体安装在纳米载体的表面上，以增强向靶组织的递送，并增强靶细胞对纳米载体的内在化，从而提高准确性，功效并最终增强患者的治疗效果。本文介绍了有关配体安装的纳米载体开发的最新进展，并讨论了其设计对生物学性能的影响。除学术成就外，还介绍了在临床试验中配体安装的纳米载体的进展，以及这些制剂面临的挑战。最后，讨论了配体安装的纳米载体的未来前景，

更新日期：2020-04-01

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