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The regulation, functions and clinical relevance of arginine methylation.
Nature Reviews Molecular Cell Biology ( IF 81.3 ) Pub Date : 2019-07-26 , DOI: 10.1038/s41580-019-0155-x
Ernesto Guccione 1 , Stéphane Richard 2
Affiliation  

Methylation of arginine residues by protein arginine methyltransferases (PRMTs) is involved in the regulation of fundamental cellular processes, including transcription, RNA processing, signal transduction cascades, the DNA damage response and liquid-liquid phase separation. Recent studies have provided considerable advances in the development of experimental tools and the identification of clinically relevant PRMT inhibitors. In this review, we discuss the regulation of PRMTs, their various cellular roles and the clinical relevance of PRMT inhibitors for the therapy of neurodegenerative diseases and cancer.

中文翻译:

精氨酸甲基化的调控,功能和临床意义。

蛋白质精氨酸甲基转移酶(PRMT)使精氨酸残基甲基化参与基本细胞过程的调控,包括转录,RNA加工,信号转导级联,DNA损伤反应和液-液相分离。最近的研究在实验工具的开发和临床相关PRMT抑制剂的鉴定方面提供了可观的进展。在这篇综述中,我们讨论了PRMT的调控,它们的各种细胞作用以及PRMT抑制剂在神经退行性疾病和癌症治疗中的临床意义。
更新日期:2019-11-18
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