Survival and specific outcome of sickle cell disease patients after renal transplantation.,British Journal of Haematology

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Survival and specific outcome of sickle cell disease patients after renal transplantation.
British Journal of Haematology ( IF 5.1 ) Pub Date : 2019-07-26 , DOI: 10.1111/bjh.16113
Christel Gérardin _{1,

2} , Anissa Moktefi _{2,

3} , Cécile Couchoud ₄ , Alyette Duquesne ₅ , Nacera Ouali ₆ , Philippe Gataut ₇ , Alexandre Karras ₈ , Dany Anglicheau _{9,

10} , Carmen Lefaucheur ₁₁ , Lucile Figueres ₁₂ , Laetitia Albano ₁₃ , Arnaud Lionet ₁₄ , Marine Novion ₁₅ , Marie-Julia Ziliotis ₁₆ , Magali Louis ₁₇ , Arnaud Del Bello ₁₈ , Marie Matignon _{1,

2} , Karine Dahan ₁₉ , Anoosha Habibi _{20,

21} , Frederic Galacteros _{20,

21} , Pablo Bartolucci _{20,

21} , Philippe Grimbert _{1,

2} , Vincent Audard _{1,

2}

Affiliation

AP-HP (Assistance Publique-Hôpitaux de Paris), Department of Nephrology and Transplantation, Rare French Disease Centre "Idiopathic Nephrotic syndrome", Henri-Mondor/Albert-Chenevier Hospital, Créteil, France.
Inserm U955, Team 21, DHU VIC, Paris-Est University, Créteil, France.
AP-HP, Department of Pathology, Henri-Mondor/Albert-Chenevier Hospital, Créteil, France.
REIN registry. Agence de la Biomédecine, Saint Denis La Plaine, France.
Department of Nephrology, André Grégoire Hospital, Montreuil, France.
AP-HP, Department of Nephrology and Transplantation, Tenon Hospital, Sorbonne University, Paris, France.
Department of Nephrology, Hypertension, Transplantation and Dialysis Bretonneau Hospital, Centre Hospitalo Universitaire (CHU) Tours, Tours, France.
AP-HP, Department of Nephrology, Européen Gorges Pompidou Hospital, Paris, France.
AP-HP, Department of Nephrology and Kidney Transplantation, Necker Hospital, Paris, France.
Descartes University, Réseau Thématique de Recherche et de Soins Centaure, LabEx Transplantex, Paris, France.
AP-HP, Department of Nephrology and Transplantation, Saint-Louis Hospital, Paris, France.
Institute of Transplantation Urology and Nephrology (ITUN), CHU Nantes, Nantes University, Nantes, France.
Department of Nephrology, Dialysis, and Renal Transplantation, CHU Nice, Nice, France.
Department of Nephrology, Transplantation and Dialysis, Huriez University Hospital, Lille, France.
Department of Nephrology, Transplantation, Dialysis and Apheresis, Pellegrin University Hospital, Bordeaux, France.
Department of Nephrology, Dialysis, and Renal Transplantation, CHU Besançon, Besançon, France.
Transplant Federation, François Mitterrand University Hospital, CHU Dijon, Dijon, France.
Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France.
AP-HP, Department of Nephrology and Dialysis, Tenon Hospital, Sorbonne University, Paris, France.
AP-HP, Sickle Cell Referral Centre, Henri-Mondor/Albert-Chenevier Hospital, Créteil, France.
Inserm U955, Team 2, DHU A-TVB, Paris-Est University, Créteil, France.

The prognosis of sickle cell disease (SCD) patients who need dialysis is poor, but experience with kidney transplantation is limited. This study assessed the characteristics of 36 SCD patients undergoing renal transplantation. Immediate post-surgical complications occurred in 25% of cases. Cytomegalovirus and bacterial infections were frequently observed. Twelve patients died after a median follow-up period of 17·4 months. Overall patient survival was significantly lower in SCD than in the control group without significant difference for overall death-censored graft survival. Our data suggest that renal transplantation should be systematically considered in SCD patients with end-stage renal disease.

中文翻译：

肾移植后镰状细胞病患者的生存和特异性转归。

需要透析的镰状细胞病（SCD）患者的预后较差，但肾移植的经验有限。这项研究评估了36名接受肾脏移植的SCD患者的特征。25％的病例立即发生手术后并发症。经常观察到巨细胞病毒和细菌感染。中位随访期为17·4个月后，有12名患者死亡。SCD患者的总生存率显着低于对照组，而总死亡检查的移植物生存率无显着差异。我们的数据表明，对于患有终末期肾脏疾病的SCD患者，应系统地考虑肾脏移植。

更新日期：2019-07-26

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