Immune checkpoint blockade therapy can elicit robust and durable responses in a variety of cancer types. While many patients do not respond, recent reports highlight a distinct group of patients whose tumors undergo rapid growth, leading to progressive disease and poor outcome. In this perspective, we synthesize and summarize some important issues surrounding hyperprogression, defining characteristics, prognostic implications, and controversies.

中文翻译：

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好的，坏的和丑陋的：免疫检查点治疗后癌症患者的过度进展。

免疫检查站封锁疗法可在多种癌症类型中引起强劲而持久的反应。尽管许多患者没有反应，但最近的报道强调了一组不同的患者，其肿瘤经历了快速生长，导致疾病进展和不良预后。从这个角度出发，我们综合并总结了围绕过度发展，定义特征，预后意义和争议的一些重要问题。