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Home environment: respiratory and allergic phenotypes from birth to age six in the PELAGIE cohort.
npj Primary Care Respiratory Medicine ( IF 3.1 ) Pub Date : 2019-07-25 , DOI: 10.1038/s41533-019-0141-y Katharina Apel 1, 2, 3 , Nathalie Costet 1 , Anthony Chapron 2, 3 , Sylvaine Cordier 1 , Christine Monfort 1 , Cécile Chevrier 1 , Fabienne Pelé 1, 2, 3
npj Primary Care Respiratory Medicine ( IF 3.1 ) Pub Date : 2019-07-25 , DOI: 10.1038/s41533-019-0141-y Katharina Apel 1, 2, 3 , Nathalie Costet 1 , Anthony Chapron 2, 3 , Sylvaine Cordier 1 , Christine Monfort 1 , Cécile Chevrier 1 , Fabienne Pelé 1, 2, 3
Affiliation
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Childhood asthma and allergies are particularly prevalent diseases. Our objective is to identify respiratory and allergic phenotypes from birth to 6 years of age, and to explore their environmental determinants, especially those related to the home environment. Data on respiratory and allergic health outcomes and domestic environmental exposure were collected for 935 mother-infant pairs from a longitudinal mother-child cohort based on mothers, included before 19 weeks of gestation in Brittany between 2002 and 2006. Information was obtained by self-administered questionnaires completed by parents at inclusion, delivery, and when the child was 2 and 6 years old. Kml3D clustering was used to describe profiles of children who shared similar trajectories of symptoms as phenotypes. Association with environmental determinants was estimated by polytomous logistic regression. Five phenotypes were identified: a reference group characterized by low symptom levels (31.1%), a transient cough phenotype (36.5%), an eczema/cough phenotype (12.3%), a wheeze/cough phenotype (11.8%), and finally a mixed phenotype (8.0%). The wheeze/cough profile was associated with postnatal exposure to glues used in renovation activities (aOR 2.3 [1.2-4.7]), and the mixed phenotype with postnatal exposure to paint (aOR 2.1 [1-4.5]). The phenotypes observed showed some consistencies with those seen in previous studies. Some exposures associated with respiratory/allergic phenotypes observed in this study are avoidable. If confirmed by further research including interventional trials, home-based environmental counseling could be a possible prevention target for primary care professionals.
中文翻译：
家庭环境：PELAGIE队列中从出生到六岁的呼吸道和过敏表型。
儿童哮喘和过敏是特别普遍的疾病。我们的目标是确定从出生到6岁的呼吸和过敏表型，并探讨它们的环境决定因素，尤其是那些与家庭环境有关的决定因素。从2002年至2006年在布列塔尼怀孕19周之前，从母亲的纵向母亲队列中收集了935对母婴的呼吸道和过敏性健康结局以及家庭环境暴露的数据。父母在纳入，分娩以及孩子2岁和6岁时填写的问卷。Kml3D聚类用于描述与症状表型具有相似症状轨迹的儿童的档案。与环境决定因素的关联通过多因素逻辑回归进行估计。确定了五种表型：特征为低症状水平的参考组（31.1％），短暂性咳嗽表型（36.5％），湿疹/咳嗽表型（12.3％），喘息/咳嗽表型（11.8％），最后是混合表型（8.0％）。喘息/咳嗽的特征与产后暴露于翻新活动中使用的胶水有关（aOR 2.3 [1.2-4.7]），与表型混合与产后暴露于油漆中（aOR 2.1 [1-4.5]）有关。观察到的表型显示出与先前研究中所见一致。在这项研究中观察到的一些与呼吸/过敏表型有关的暴露是可以避免的。如果经包括介入试验在内的进一步研究证实，
更新日期：2019-07-25
中文翻译：
家庭环境：PELAGIE队列中从出生到六岁的呼吸道和过敏表型。
儿童哮喘和过敏是特别普遍的疾病。我们的目标是确定从出生到6岁的呼吸和过敏表型，并探讨它们的环境决定因素，尤其是那些与家庭环境有关的决定因素。从2002年至2006年在布列塔尼怀孕19周之前，从母亲的纵向母亲队列中收集了935对母婴的呼吸道和过敏性健康结局以及家庭环境暴露的数据。父母在纳入，分娩以及孩子2岁和6岁时填写的问卷。Kml3D聚类用于描述与症状表型具有相似症状轨迹的儿童的档案。与环境决定因素的关联通过多因素逻辑回归进行估计。确定了五种表型：特征为低症状水平的参考组（31.1％），短暂性咳嗽表型（36.5％），湿疹/咳嗽表型（12.3％），喘息/咳嗽表型（11.8％），最后是混合表型（8.0％）。喘息/咳嗽的特征与产后暴露于翻新活动中使用的胶水有关（aOR 2.3 [1.2-4.7]），与表型混合与产后暴露于油漆中（aOR 2.1 [1-4.5]）有关。观察到的表型显示出与先前研究中所见一致。在这项研究中观察到的一些与呼吸/过敏表型有关的暴露是可以避免的。如果经包括介入试验在内的进一步研究证实，
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