BACKGROUND Although some studies have reported significant reductions in food cravings following the single-session of repetitive transcranial magnetic stimulation (rTMS), there is little research on the effects of multi-session of rTMS on food consumption and body weight in obese subjects. OBJECTIVE We conducted 4-week randomized, sham-controlled, single-blind, parallel-group trial to examine the effect of rTMS on body weight in obese adults. METHODS Forty-three obese patients (body mass index [BMI] ≥25 kg/m2) aged between 18 and 70 years were randomized to the sham or real treatment group (21 in the TMS group and 22 in the sham treatment group). A total of 8 sessions of rTMS targeting the left dorsolateral prefrontal cortex (DLPFC) was provided over a period of 4 weeks. The primary outcome measure was weight change in kilograms from baseline to 4 weeks. Secondary endpoints included changes in anthropometric measures, cardiovascular risk factors, food intake, and appetite. RESULTS Participants in the rTMS group showed significantly greater weight loss from baseline following the 8 session of rTMS (-2.75 ± 2.37 kg vs. 0.38 ± 1.0 kg, p < 0.01). Consistent with weight loss, there was a significant reduction in fat mass and visceral adipose tissue at week 4 in the rTMS group compared with the control group (p < 0.01). After the 8 sessions of rTMS, the TMS group consumed fewer total kilocalories and carbohydrates per day than the control group (p < 0.05). CONCLUSIONS 8 sessions of HF rTMS delivered to the left DLPFC were effective in inducing weight loss and decreasing food intake in obese patients. TRIAL REGISTRATION Clinical trial registered with the Clinical Trials Registry at http://cris.cdc.go.kr (KCT0002548).

中文翻译：

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重复经颅磁刺激对肥胖成人体重和食物消耗的影响：一项随机对照研究

背景尽管一些研究报告了单次重复经颅磁刺激 (rTMS) 后对食物的渴望显着减少，但关于多次重复经颅磁刺激 (rTMS) 对肥胖受试者食物消耗和体重的影响的研究很少。目的 我们进行了为期 4 周的随机、假手术对照、单盲、平行组试验，以检查 rTMS 对肥胖成人体重的影响。方法 43 名年龄在 18 至 70 岁之间的肥胖患者（体重指数 [BMI] ≥25 kg/m2）随机分为假治疗组或真实治疗组（TMS 组 21 例，假治疗组 22 例）。在 4 周的时间里，总共提供了 8 次针对左背外侧前额叶皮层 (DLPFC) 的 rTMS。主要结果指标是从基线到 4 周的体重变化（公斤）。次要终点包括人体测量、心血管危险因素、食物摄入量和食欲的变化。结果 rTMS 组的参与者在 rTMS 的第 8 个疗程后表现出比基线显着更大的体重减轻（-2.75 ± 2.37 kg vs. 0.38 ± 1.0 kg，p < 0.01）。与体重减轻一致，与对照组相比，rTMS 组在第 4 周的脂肪量和内脏脂肪组织显着减少（p < 0.01）。经过 8 次 rTMS 治疗后，TMS 组每天消耗的总热量和碳水化合物比对照组少（p < 0.05）。结论 向左侧 DLPFC 进行 8 次 HF rTMS 治疗可有效诱导肥胖患者体重减轻和减少食物摄入。