BACKGROUND The individual α frequency (IAF) has been associated with the outcome of repetitive Transcranial Magnetic Stimulation (rTMS) treatment of Major Depressive Disorder (MDD), but the association has been inconsistent. HYPOTHESIS Proximity of IAF to the stimulation frequency, rather than the value of IAF per se, is associated with outcome for patients receiving 10 Hz rTMS. METHODS We examined the relationships between IAF, rTMS stimulation frequency, and treatment outcome in 147 patients. All patients initially received 10 Hz rTMS unilateral treatment delivered to left dorsolateral prefrontal cortex (DLPFC) (10UL), with subsets of patients changed to unilateral 5 Hz to left DLPFC (5UL) or sequential bilateral (SB) stimulation (10 Hz/1Hz) to left and right DLPFC based upon worsening symptoms with or intolerance of 10UL. Outcome was percent change in total score on the Inventory of Depressive Symptomatology - Self Report (IDS-SR) scale from pre-treatment baseline to the 30th treatment. IAF values and absolute difference between IAF and 10 Hz (|IAF-10Hz|) were examined in relation to outcome for the overall sample and for each stimulation group separately. RESULTS There was no correlation between IAF value, or |IAF-10Hz| and outcome in the overall sample. ANCOVA showed a significant interaction between IAF measures and treatment type. Post-hoc analyses revealed that IAF and |IAF-10Hz| were both significantly associated with degree of improvement (IDS-SR % change) for patients who received 10UL (P < 0.01) but not 5UL or SB stimulation. There was a trend-level difference in IAF between responders and non-responders only within the 10 Hz group, but not within the other treatment groups (n.s.). For the 10UL group, membership in the highest IAF quartile was associated with significantly greater clinical improvement than membership in the lowest IAF quartile (p = 0.0034). CONCLUSIONS IAF measures were associated with clinical outcome of patients treated with 10UL but not 5UL or SB rTMS treatment. This suggests that interactions between endogenous frequencies and treatment outcome may be related to the selected stimulation parameters and/or physiologic and clinical characteristics of patients who benefit from those parameters.

中文翻译：

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重复经颅磁刺激 (rTMS) 治疗重度抑郁症 (MDD) 的个体 α 峰值频率与临床结果之间的关系

背景 个体 α 频率 (IAF) 与重复经颅磁刺激 (rTMS) 治疗重度抑郁症 (MDD) 的结果相关，但这种关联并不一致。假设 IAF 与刺激频率的接近程度，而不是 IAF 本身的值，与接受 10 Hz rTMS 的患者的结果相关。方法 我们检查了 147 名患者的 IAF、rTMS 刺激频率和治疗结果之间的关系。所有患者最初接受 10 Hz rTMS 单侧治疗，左背外侧前额叶皮层 (DLPFC) (10UL)，部分患者改为单侧 5 Hz 至左 DLPFC (5UL) 或顺序双侧 (SB) 刺激 (10 Hz/1Hz)基于 10UL 或不耐受 10UL 的症状恶化，对左右 DLPFC 进行调整。结果是抑郁症状清单 - 自我报告 (IDS-SR) 量表从治疗前基线到第 30 次治疗的总分变化百分比。IAF 值和 IAF 与 10 Hz 之间的绝对差异 (|IAF-10Hz|) 分别与整个样本和每个刺激组的结果相关。结果 IAF 值或|IAF-10Hz| 之间没有相关性。和总体样本中的结果。ANCOVA 显示 IAF 措施和治疗类型之间存在显着的相互作用。事后分析显示 IAF 和 |IAF-10Hz| 均与接受 10UL (P < 0.01) 但不接受 5UL 或 SB 刺激的患者的改善程度（IDS-SR % 变化）显着相关。仅在 10 Hz 组内，响应者和非响应者之间的 IAF 存在趋势水平差异，但不在其他治疗组 (ns) 内。对于 10UL 组，最高 IAF 四分位数的成员资格比最低 IAF 四分位数的成员资格显着更大的临床改善相关 (p = 0.0034)。结论 IAF 测量值与接受 10UL 而非 5UL 或 SB rTMS 治疗的患者的临床结果相关。这表明内源性频率和治疗结果之间的相互作用可能与选择的刺激参数和/或受益于这些参数的患者的生理和临床特征有关。结论 IAF 测量值与接受 10UL 而非 5UL 或 SB rTMS 治疗的患者的临床结果相关。这表明内源性频率和治疗结果之间的相互作用可能与选择的刺激参数和/或受益于这些参数的患者的生理和临床特征有关。结论 IAF 测量值与接受 10UL 而非 5UL 或 SB rTMS 治疗的患者的临床结果相关。这表明内源性频率和治疗结果之间的相互作用可能与选择的刺激参数和/或受益于这些参数的患者的生理和临床特征有关。