当前位置: X-MOL 学术Trends Endocrin. Met. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Antagonism between Antiviral Signaling and Glycolysis
Trends in Endocrinology & Metabolism ( IF 11.4 ) Pub Date : 2019-09-01 , DOI: 10.1016/j.tem.2019.07.010
Anoop Singh Chauhan 1 , Li Zhuang 2 , Boyi Gan 2
Affiliation  

RIG-I-like receptor (RLR)-mediated interferon production is critical for antiviral responses. A recent study (Zhang et al., Cell, 2019) uncovered a reciprocal inhibition between RLR signaling and glycolysis: lactate produced by glycolysis inhibits RLR signaling by binding to RLR signaling component mitochondrial antiviral-signaling (MAVS), whereas RLR activation suppresses glycolysis through inhibiting glycolysis enzyme hexokinase.

中文翻译:

抗病毒信号与糖酵解之间的拮抗作用

RIG-I 样受体 (RLR) 介导的干扰素产生对于抗病毒反应至关重要。最近的一项研究 (Zhang et al., Cell, 2019) 揭示了 RLR 信号和糖酵解之间的相互抑制:糖酵解产生的乳酸通过与 RLR 信号成分线粒体抗病毒信号 (MAVS) 结合来抑制 RLR 信号,而 RLR 激活通过抑制糖酵解酶己糖激酶。
更新日期:2019-09-01
down
wechat
bug