Selenium-Catalyzed Carbonylative Synthesis of 3,4-Dihydroquinazolin-2(1H)-one Derivatives with TFBen as the CO Source.,ACS Combinatorial Science

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Selenium-Catalyzed Carbonylative Synthesis of 3,4-Dihydroquinazolin-2(1H)-one Derivatives with TFBen as the CO Source.
ACS Combinatorial Science Pub Date : 2019-07-23 , DOI: 10.1021/acscombsci.9b00090
Rong Zhou ₁ , Xinxin Qi ₁ , Xiao-Feng Wu _{1,

2}

Affiliation

An efficient and general carbonylative procedure for the synthesis of 3,4-dihydroquinazolin-2(1H)-one from 1-(halomethyl)-2-nitrobenzenes and aryl/alkyl amines have been explored. In this approach, to avoid of using toxic CO gas, a solid and stable CO precursor, TFBen (benzene-1,3,5-triyl triformate), was utilized. With elemental selenium as the catalyst, a variety of aryl/alkyl amines has been tolerated well to afford the corresponding 3,4-dihydroquinazolin-2(1H)-one products in moderate to excellent yields under mild reaction condition.

中文翻译：

以TFBen为CO源的硒催化3,4-二氢喹唑啉-2（1H）-one衍生物的羰基化合成。

已经研究了由1-（卤甲基）-2-硝基苯和芳基/烷基胺合成3,4-二氢喹唑啉-2（1H）-一的有效且通用的羰基化方法。在这种方法中，为避免使用有毒的CO气体，使用了固态且稳定的CO前驱物TFBen（苯甲酸1,3,5-5-三甲酸三乙酯）。以元素硒为催化剂，可以很好地耐受各种芳基/烷基胺，从而在温和的反应条件下以中等至极好的收率得到相应的3,4-二氢喹唑啉-2（1H）-一产物。

更新日期：2019-07-18

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