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Reduced expression of ferroportin1 and ceruloplasmin predicts poor prognosis in adrenocortical carcinoma.
Journal of Trace Elements in Medicine and Biology ( IF 3.6 ) Pub Date : 2019-07-23 , DOI: 10.1016/j.jtemb.2019.07.009 Bo Zhu 1 , Qi Zhi 2 , Qian Xie 1 , Xiaohui Wu 1 , Yanan Gao 1 , Xiao Chen 3 , Liyun Shi 1
Journal of Trace Elements in Medicine and Biology ( IF 3.6 ) Pub Date : 2019-07-23 , DOI: 10.1016/j.jtemb.2019.07.009 Bo Zhu 1 , Qi Zhi 2 , Qian Xie 1 , Xiaohui Wu 1 , Yanan Gao 1 , Xiao Chen 3 , Liyun Shi 1
Affiliation
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INTRODUCTION
Iron metabolism is tightly controlled in human cells. Dysregulation of iron metabolism-related genes has been characterized as a promising prognostic biomarker in cancers. However, the expression patterns and prognostic roles of iron metabolism-related genes remain unknown in adrenocortical carcinoma (ACC).
OBJECTIVES
The primary objective of this study was to explore the expression patterns and prognostic roles of iron metabolism-related genes in ACC using publicly available datasets.
METHODS
In the present study, we compared the expression patterns of 36 iron metabolism-related genes between ACC tumors (n = 77) and normal adrenal tissues (n = 128) based on The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) data. The associations between clinical variables (including survival rate and pathological stage) and expression levels of iron mentalism-related genes were further explored. All the bioinformatics analyses were performed using the GEPIA or the Metascape tool.
RESULTS
Twelve iron metabolism-related genes were differentially expressed between ACC tumors and normal controls. Among them, reduced expression levels of ferroportin1 (FPN1) and ceruloplasmin (CP) were significantly correlated with poor survival of ACC patients. Specially, the expression levels of FPN1 were negatively correlated with the pathological stages of ACC. A pan-cancer analysis characterized the reduced expression of FPN1 and CP as an ACC-specific signature among 33 types of cancers. Functional enrichment analysis suggested that both FPN1 and CP might be implicated in several immune processes.
CONCLUSION
Reduced expression of FPN1 and CP was identified as a potential signature for poor prognosis of ACC in this study. Mechanisms underlying the prognostic value of FPN1 or CP in ACC deserve further experimental investigation.
中文翻译：
Ferroportin1和铜蓝蛋白表达的降低预示着肾上腺皮质癌的不良预后。
简介铁代谢在人类细胞中受到严格控制。铁代谢相关基因的失调已被表征为癌症中有希望的预后生物标志物。然而，铁代谢相关基因的表达模式和预后作用在肾上腺皮质癌（ACC）中仍然未知。目的本研究的主要目的是使用可公开获得的数据集探讨铁代谢相关基因在ACC中的表达模式和预后作用。方法在本研究中，我们根据癌症基因组图谱（TCGA）和基因型组织表达，比较了ACC肿瘤（n = 77）和正常肾上腺组织（n = 128）之间36种与铁代谢相关的基因的表达模式。 （GTEx）数据。进一步探讨了临床变量（包括生存率和病理分期）与铁性精神病相关基因表达水平之间的关联。所有生物信息学分析均使用GEPIA或Metascape工具进行。结果ACC肿瘤与正常对照组中有十二个铁代谢相关基因差异表达。其中，铁转运蛋白1（FPN1）和铜蓝蛋白（CP）的表达水平降低与ACC患者的不良生存率显着相关。特别地，FPN1的表达水平与ACC的病理阶段呈负相关。泛癌分析的特征是FPN1和CP的表达减少，这是33种类型的癌症中的ACC特异性标志。功能富集分析表明FPN1和CP可能都涉及几个免疫过程。结论在本研究中，FPN1和CP的表达降低被认为是ACC预后不良的潜在特征。FPN1或CP对ACC预后价值的潜在机制值得进一步的实验研究。
更新日期：2019-07-23
中文翻译：
Ferroportin1和铜蓝蛋白表达的降低预示着肾上腺皮质癌的不良预后。
简介铁代谢在人类细胞中受到严格控制。铁代谢相关基因的失调已被表征为癌症中有希望的预后生物标志物。然而，铁代谢相关基因的表达模式和预后作用在肾上腺皮质癌（ACC）中仍然未知。目的本研究的主要目的是使用可公开获得的数据集探讨铁代谢相关基因在ACC中的表达模式和预后作用。方法在本研究中，我们根据癌症基因组图谱（TCGA）和基因型组织表达，比较了ACC肿瘤（n = 77）和正常肾上腺组织（n = 128）之间36种与铁代谢相关的基因的表达模式。 （GTEx）数据。进一步探讨了临床变量（包括生存率和病理分期）与铁性精神病相关基因表达水平之间的关联。所有生物信息学分析均使用GEPIA或Metascape工具进行。结果ACC肿瘤与正常对照组中有十二个铁代谢相关基因差异表达。其中，铁转运蛋白1（FPN1）和铜蓝蛋白（CP）的表达水平降低与ACC患者的不良生存率显着相关。特别地，FPN1的表达水平与ACC的病理阶段呈负相关。泛癌分析的特征是FPN1和CP的表达减少，这是33种类型的癌症中的ACC特异性标志。功能富集分析表明FPN1和CP可能都涉及几个免疫过程。结论在本研究中，FPN1和CP的表达降低被认为是ACC预后不良的潜在特征。FPN1或CP对ACC预后价值的潜在机制值得进一步的实验研究。
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