MOTIVATION Adverse outcome pathway (AOP) is a toxicological concept proposed to provide a mechanistic representation of biological perturbation over different layers of biological organization. Although AOPs are by definition chemical-agnostic, many chemical stressors can putatively interfere with one or several AOPs and such information would be relevant for regulatory decision-making. RESULTS With the recent development of AOPs networks aiming to facilitate the identification of interactions among AOPs, we developed a stressor-AOP network (sAOP). Using the 'cytotoxitiy burst' (CTB) approach, we mapped bioactive compounds from the ToxCast data to a list of AOPs reported in AOP-Wiki database. With this analysis, a variety of relevant connections between chemicals and AOP components can be identified suggesting multiple effects not observed in the simplified 'one-biological perturbation to one-adverse outcome' model. The results may assist in the prioritization of chemicals to assess risk-based evaluations in the context of human health. AVAILABILITY AND IMPLEMENTATION sAOP is available at http://saop.cpr.ku.dk. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.

中文翻译：

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sAOP：将化学应激源与不良结果通路网络联系起来。

动机 不良结果途径 (AOP) 是一种毒理学概念，旨在提供对不同生物组织层的生物扰动的机械表示。尽管 AOP 根据定义与化学物质无关，但许多化学应激源可能会干扰一种或多种 AOP，并且此类信息与监管决策相关。结果 随着 AOPs 网络的最新发展旨在促进 AOPs 之间相互作用的识别，我们开发了压力源 AOP 网络 (sAOP)。使用“细胞毒性爆发”(CTB) 方法，我们将 ToxCast 数据中的生物活性化合物映射到 AOP-Wiki 数据库中报告的 AOP 列表。有了这个分析，可以确定化学品和 AOP 成分之间的各种相关联系，这表明在简化的“一种生物扰动到一种不利结果”模型中没有观察到多种影响。结果可能有助于确定化学品的优先次序，以评估人类健康背景下基于风险的评估。可用性和实施​​ sAOP 可在 http://saop.cpr.ku.dk 获得。补充信息 补充数据可在 Bioinformatics 在线获得。