Organs-on-chips (OoCs) have attracted significant attention because they can be designed to mimic in vivo environments. Beyond constructing a single OoC, recent efforts have tried to integrate multiple OoCs to broaden potential applications such as disease modeling and drug discoveries. However, various challenges remain for integrating OoCs towards in vivo-like operation, such as incorporating various connections for integrating multiple OoCs. We review multiplexed OoCs and challenges they face: scaling, vascularization, and innervation. In our opinion, future OoCs will be constructed to have increased predictive power for in vivo phenomena and will ultimately become a mainstream tool for high quality biomedical and pharmaceutical research.

中文翻译：

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整合器官器官：多路复用，缩放，血管化和神经支配。

芯片上的器官（OoC）受到了广泛的关注，因为它们可以设计为模仿体内环境。除了构建单个OoC，最近的努力还尝试将多个OoC集成在一起，以拓宽疾病建模和药物发现等潜在应用。但是，将OoC集成到类似体内的操作中仍然面临各种挑战，例如合并各种连接以集成多个OoC。我们回顾了多重OoC及其面临的挑战：缩放，血管化和神经支配。我们认为，未来的OoC将被构建为具有增强的体内现象预测能力，并将最终成为高质量生物医学和药物研究的主流工具。