BACKGROUND An increasing number of patients undergoing liver resection are of advancing age. The impact of ageing on liver regeneration and post-operative outcomes following a major resection are uncertain. We aimed to investigate risk factors for patients who developed Post Hepatectomy Liver Failure (PHLF) following right hepatectomy with age as the primary risk-factor. METHOD Patients undergoing right hepatectomy between July 2004-July 2018 were included. ROC analysis was performed to identify at which age PHLF development-risk increased. Secondary endpoints were length of stay (LOS), complications, and cost. RESULTS 332-patients were included. ROC demonstrated a cut-off age of 75-years in which PHLF risk increased. >75 there was an increased risk of PHLF (35% >75yrs vs. 7% <75yrs (p = <0.001), OR = 8.8 (95% CI = 3.6-21)) There was no difference between the age groups for any other PHLF risk factor. Patients >75yrs had longer LOS (11-days vs. 7-days (p = 0.04). Patients who developed PHLF had increased hospital costs: £10,987.50 (£6175-£46,050) vs. £2575 (£900-£46,050 p = 0.01). CONCLUSIONS Patients >75yrs have increased risk of developing PHLF after right hepatectomy, contributing to increased mortality and economic burden. Pre-operatively identifying patients at-risk of PHLF is important to consider liver volume optimization strategies and improve outcomes.

中文翻译：

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年龄对右肝切除术后肝功能的影响：回顾性，单中心经验。

背景技术进行肝切除术的患者的年龄正在增长。大手术后衰老对肝脏再生和术后结果的影响尚不确定。我们旨在调查以年龄为主要危险因素的右肝切除术后发生肝切除术后肝衰竭（PHLF）的患者的危险因素。方法纳入2004年7月至2018年7月之间接受右肝切除术的患者。进行了ROC分析，以确定PHLF发生风险在哪个年龄段增加。次要终点是住院时间（LOS），并发症和费用。结果包括332名患者。ROC的临界年龄为75岁，其中PHLF风险增加。> 75时发生PHLF的风险增加（35％> 75年vs. 7％<75年（p = <0.001），OR = 8.8（95％CI = 3。6-21））其他PHLF危险因素在年龄组之间没有差异。> 75岁的患者有较长的LOS（11天vs 7天（p = 0.04）。发生PHLF的患者住院费用增加：£10,987.50（£6175-£46,050）vs.£2575（£900-£46,050 p = 0.01）结论>> 75岁的患者在右肝切除后发生PHLF的风险增加，导致死亡率和经济负担的增加，术前确定有PHLF危险的患者对于考虑优化肝容量策略和改善结局非常重要。75岁的人右肝切除后发生PHLF的风险增加，导致死亡率增加和经济负担增加。术前确定有PHLF危险的患者对于考虑优化肝脏容量优化策略和改善结局非常重要。75岁的人右肝切除后发生PHLF的风险增加，导致死亡率增加和经济负担增加。术前确定有PHLF危险的患者对于考虑优化肝脏容量优化策略和改善结局非常重要。