BACKGROUND Biopsies of dysplastic nevi processed by bread-loafing allow for limited margin assessment; however, reported biopsy margins often influence management. OBJECTIVE To evaluate the negative predictive value of biopsy margins of dysplastic nevi. METHODS A retrospective search of a single academic institution's pathology database was conducted to identify all biopsy specimens of dysplastic nevi between January 1, 2015, and December 31, 2017. Biopsy specimen margin assessments were compared with excision pathology reports to calculate negative predictive value and to assess the frequency of residual nevus on excision after positive biopsy margins. RESULTS A total of 1245 dysplastic nevi from 934 patients were identified. Clear biopsy margins had a negative predictive value for the absence of residual nevus on excision of 87.3% for dysplastic nevi of moderate atypia or greater. Residual nevus was identified on excision in 29.41% of cases of dysplastic nevi of moderate atypia or greater when initial biopsy margins were positive. LIMITATIONS This was a retrospective, single-institution study. The calculations likely overestimate the true negative predictive value of biopsy margins because of processing of excision specimens by bread-loafing. CONCLUSIONS This study provides additional evidence that reported biopsy margins are not representative of true margin status.

中文翻译：

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增生痣活检切缘的阴性预测价值：单机构回顾性研究。

背景技术通过面包包扎处理的增生痣活检可以进行有限的切缘评估。但是，报告的活检切缘通常会影响管理。目的评价增生痣活检切缘的阴性预测价值。方法回顾性研究单个学术机构的病理数据库，以鉴定2015年1月1日至2017年12月31日期间所有增生痣的活检标本。将活检标本评估与切除病理报告进行比较，以计算阴性预测值，并评估活检切缘阳性后切除后残留痣的发生频率。结果共鉴定出934例患者中的1245例增生痣。明确的活检切缘对87例切除后没有残留痣的患者具有负的预测价值。中度异型或更大异型增生性痣为3％。当初次活检切缘阳性时，切除后残留痣在29.41％的中度异型或更大异型增生异常痣中被发现。局限性这是一项回顾性的单机构研究。该计算可能会高估活检切缘的真实阴性预测值，这是因为通过面包处理切下的标本。结论这项研究提供了额外的证据，表明活检切缘不代表真实切缘状态。该计算可能会高估活检切缘的真实阴性预测值，这是因为通过面包处理切下的标本。结论这项研究提供了额外的证据，表明活检切缘不代表真实切缘状态。该计算可能会高估活检切缘的真实阴性预测值，这是因为通过面包处理切下的标本。结论这项研究提供了额外的证据，表明活检切缘不代表真实切缘状态。