Two new diketopiperazines (1, 2), one new polyprenol (3), together with 19 known compounds (4-22) were obtained from the EtOAc extract of Bionectria sp. Y1085, an endophytic fungus isolated from the plant Huperzia serrata. Their structures were elucidated by extensive NMR and MS analysis. Bionectin D (1) is a rare diketopiperazine with a single methylthio substitution at the α-carbon of cyclized amino acid residue. The antibacterial activity of compounds was assayed against Escherichia coli, Staphylococcus aureus, and Salmonella typhimurium ATCC 6539, and some metabolites (1, 2, 10, 11, and 14) exhibited evident antibacterial activity.

中文翻译：

---

内生真菌Bionectria sp。的抗菌二酮哌嗪。Y1085。

从Bionectria sp。的EtOAc提取物中获得了两种新的二酮哌嗪（1，2），一种新的聚戊二烯（3）以及19种已知的化合物（4-22）。Y1085，一种从植物石杉石楠中分离出的内生真菌。通过广泛的NMR和MS分析阐明了它们的结构。Bionectin D（1）是一种稀有的二酮哌嗪，在环化氨基酸残基的α-碳上具有单个甲硫基取代基。测定了化合物对大肠杆菌，金黄色葡萄球菌和鼠伤寒沙门氏菌ATCC 6539的抗菌活性，某些代谢产物（1、2、10、11和14）表现出明显的抗菌活性。