Changes in cell metabolism and metabolic adaptation are hallmark features of many cancers, including leukemia, that support biological processes involved into tumor initiation, growth, and response to therapeutics. The discovery of mutations in key metabolic enzymes has highlighted the importance of metabolism in cancer biology and how these changes might constitute an Achilles heel for cancer treatment. In this Review, we discuss the role of metabolic and mitochondrial pathways dysregulated in acute myeloid leukemia, and the potential of therapeutic intervention targeting these metabolic dependencies on the proliferation, differentiation, stem cell function and cell survival to improve patient stratification and outcomes.

中文翻译：

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利用代谢脆弱性对急性髓系白血病进行个性化治疗。

细胞代谢和代谢适应的变化是包括白血病在内的许多癌症的标志特征，它们支持涉及肿瘤发生、生长和治疗反应的生物过程。关键代谢酶突变的发现凸显了代谢在癌症生物学中的重要性，以及这些变化如何构成癌症治疗的致命弱点。在这篇综述中，我们讨论了急性髓系白血病中代谢和线粒体途径失调的作用，以及针对这些代谢依赖性对增殖、分化、干细胞功能和细胞存活的治疗干预的潜力，以改善患者分层和结果。