This review discusses the current state of the viral metabolism field and gaps in knowledge that will be important for future studies to investigate. We discuss metabolic rewiring caused by viruses, the influence of oncogenic viruses on host cell metabolism, and the use of viruses as guides to identify critical metabolic nodes for cancer anabolism. We also discuss the need for more mechanistic studies identifying viral proteins responsible for metabolic hijacking and for in vivo studies of viral-induced metabolic rewiring. Improved technologies for detailed metabolic measurements and genetic manipulation will lead to important discoveries over the next decade.

中文翻译：

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病毒劫持细胞代谢。


这篇综述讨论了病毒代谢领域的现状以及知识空白，这对于未来的研究调查非常重要。我们讨论病毒引起的代谢重连、致癌病毒对宿主细胞代谢的影响，以及使用病毒作为指导来识别癌症合成代谢的关键代谢节点。我们还讨论了需要进行更多的机制研究，以确定负责代谢劫持的病毒蛋白，以及病毒诱导的代谢重连的体内研究。详细代谢测量和基因操作的改进技术将在未来十年带来重要发现。