Tissue shape emerges from the collective mechanical properties and behavior of individual cells and the ways by which they integrate into the surrounding tissue. Tissue architecture and its dynamic changes subsequently feed back to guide cell behavior. The skin is a dynamic, self-renewing barrier that is subjected to large-scale extrinsic mechanical forces throughout its lifetime. The ability to withstand this constant mechanical stress without compromising its integrity as a barrier requires compartment-specific structural specialization and the capability to sense and adapt to mechanical cues. This review discusses the unique mechanical properties of the skin and the importance of signals that arise from mechanical communication between cells and their environment.

中文翻译：

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皮肤中的机械力：在组织结构，稳定性和功能中的作用。

组织的形状来自单个细胞的集体机械特性和行为，以及它们整合到周围组织中的方式。组织结构及其动态变化随后反馈以指导细胞行为。皮肤是一种动态的，自我更新的屏障，在其整个生命周期中都会受到大规模的外在机械力的作用。承受这种恒定的机械应力而不损害其作为屏障的完整性的能力需要特定于隔室的结构专业化以及感知和适应机械提示的能力。这篇评论讨论了皮肤的独特机械特性以及细胞与周围环境之间的机械交流产生的信号的重要性。