The bacterial cell wall provides structural integrity to the cell and protects the cell from internal pressure and the external environment. During the course of the twelve-year funding period of the Collaborative Research Center 766, our work has focused on conducting structure-function studies of enzymes that modify (synthesize or cleave) cell wall components of a range of bacteria including Staphylococcus aureus, Staphylococcus epidermidis, and Nostoc punctiforme. Several of our structures represent promising targets for interference. In this review, we highlight a recent structure-function analysis of an enzyme complex that is responsible for the amidation of Lipid II, a peptidoglycan precursor, in S. aureus.

细菌细胞壁为细胞提供结构完整性，并保护细胞免受内部压力和外部环境的影响。在766协作研究中心的十二年资助期间，我们的工作重点是进行修饰（合成或切割）包括金黄色葡萄球菌，表皮葡萄球菌在内的多种细菌的细胞壁成分的酶的结构功能研究。和点状鼻头虫。我们的几个结构代表了有希望的干扰目标。在这篇综述中，我们重点介绍了一种酶复合物的近期结构-功能分析，该酶复合物负责金黄色葡萄球菌脂肽II（一种肽聚糖前体）的酰胺化。