Viral vector: potential therapeutic for glioblastoma multiforme.,Cancer Gene Therapy

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Viral vector: potential therapeutic for glioblastoma multiforme.
Cancer Gene Therapy ( IF 4.8 ) Pub Date : 2019-07-18 , DOI: 10.1038/s41417-019-0124-8
Ceera Manikandan ₁ , Akshita Kaushik ₁ , Dwaipayan Sen ₁

Affiliation

Glioblastoma multiforme is a highly malignant primary brain tumour found in adults and is highlighted as the most devastating among all the other grades of glioma. Well-established standard treatment methods, such as chemotherapy, radiation and surgery, have resulted in modest improvement in the survival of patients. Hence, the arduous search for novel treatments backed by advancements in molecular biology still persists. Glioblastoma has many distinctive characteristics, which makes it a potential candidate for gene therapy. Gene therapy involves the delivery of genetic material of therapeutic use into tumour cells, which produces a specific antitumour response. Moreover, viruses stimulate a vigorous cytotoxic effect, they are easily modifiable and the inherent property of horizontal transfer of genetic material makes them valuable tools for genetic engineering. In this review, we have enlisted the various viral vectors employed in gene therapy for glioblastoma.

中文翻译：

病毒载体：多形性胶质母细胞瘤的潜在治疗剂。

多形胶质母细胞瘤是一种在成年人中发现的高度恶性的原发性脑瘤，在所有其他等级的神经胶质瘤中，胶质母细胞瘤被认为是最具破坏性的。完善的标准治疗方法，例如化学疗法，放射疗法和手术，已导致患者存活率的适度提高。因此，在分子生物学进展的支持下，对新疗法的艰苦探索仍在继续。胶质母细胞瘤具有许多独特的特征，使其成为基因治疗的潜在候选者。基因治疗涉及将治疗用途的遗传物质传递到肿瘤细胞中，从而产生特异性的抗肿瘤反应。此外，病毒会刺激细胞毒性，它们很容易修改，遗传物质水平转移的内在特性使其成为遗传工程的重要工具。在这篇综述中，我们征集了用于胶质母细胞瘤基因治疗的各种病毒载体。

更新日期：2019-07-18

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