Monoclonal antibodies can mediate protection against Ebola virus (EBOV) infection through direct neutralization as well as through the recruitment of innate immune effector functions. However, the antibody functional response following survival of acute EBOV disease has not been well characterized. In this study, serum antibodies from Ebola virus disease (EVD) survivors from Sierra Leone were profiled to capture variation in overall subclass/isotype abundance, neutralizing activity, and innate immune effector functions. Antibodies from EVD survivors exhibited robust innate immune effector functions, mediated primarily by IgG1 and IgA1. In conclusion, development of functional antibodies follows survival of acute EVD.

中文翻译：

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埃博拉病毒病的幸存者发展出多功能抗体反应。

单克隆抗体可以通过直接中和以及通过募集先天免疫效应子功能来介导针对埃博拉病毒（EBOV）感染的保护作用。但是，急性EBOV病生存后的抗体功能反应尚未得到很好的表征。在这项研究中，对来自塞拉利昂的埃博拉病毒病（EVD）幸存者的血清抗体进行了分析，以捕获总体亚类/同种型丰度，中和活性和先天免疫效应子功能的变化。EVD幸存者的抗体表现出强大的先天免疫效应子功能，主要由IgG1和IgA1介导。总之，功能性抗体的开发遵循急性EVD的生存。