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A pro-inflammatory CD8+ T-cell subset patrols the cervicovaginal tract.
Mucosal Immunology ( IF 7.9 ) Pub Date : 2019-07-16 , DOI: 10.1038/s41385-019-0186-9
Laura Pattacini 1 , Amanda Woodward Davis 1 , Julie Czartoski 1 , Florian Mair 1 , Scott Presnell 2 , Sean M Hughes 3 , Ollivier Hyrien 1, 4 , Gretchen M Lentz 3 , Anna C Kirby 3 , Michael F Fialkow 3 , Florian Hladik 3 , Martin Prlic 1 , Jennifer M Lund 1, 5
Affiliation  

The immune system of the cervicovaginal tract (CVT) must balance immunosurveillance and active immunity against pathogens with maintenance of tolerance to resident microbiota and to fetal and partner antigens for reproductive purposes. Thus, we predicted that CVT immunity is characterized by distinctive features compared to blood and other tissue compartments. Indeed, we found that CVT CD8+ T-cells had unique transcriptional profiles, particularly in their cytokine signature, compared to that reported for CD8+ T-cells in other tissue sites. Among these CVT CD8+ T-cells, we identified a CD69- CD103- subset that was characterized by reduced migration in response to tissue-exit signals and higher pro-inflammatory potential as compared to their blood counterpart. These inflammatory mucosal CD8+ T-cells (Tim) were increased in frequency in the CVT of individuals with chronic infection, pointing to a potential role in perpetuating inflammation. Our findings highlight the specialized nature of immunity within the CVT and identify Tim cells as potential therapeutic targets to tame tissue inflammation upon chronic infection.

中文翻译:

促炎性 CD8+ T 细胞亚群在宫颈阴道巡逻。

宫颈阴道 (CVT) 的免疫系统必须在免疫监视和针对病原体的主动免疫与维持对常驻微生物群以及出于生殖目的的胎儿和伴侣抗原的耐受性之间取得平衡。因此,我们预测,与血液和其他组织隔室相比,CVT 免疫具有独特的特征。事实上,我们发现 CVT CD8+ T 细胞与其他组织部位的 CD8+ T 细胞相比具有独特的转录谱,尤其是在它们的细胞因子特征方面。在这些 CVT CD8+ T 细胞中,我们发现了一个 CD69- CD103- 亚群,其特征是响应组织退出信号的迁移减少,并且与其血液对应物相比具有更高的促炎潜力。这些炎性粘膜 CD8+ T 细胞 (Tim) 在患有慢性感染的个体的 CVT 中频率增加,表明在持续炎症中的潜在作用。我们的研究结果突出了 CVT 内免疫的特殊性质,并将 Tim 细胞确定为潜在的治疗靶点,以抑制慢性感染后的组织炎症。
更新日期:2019-11-18
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