In many settings, tumor-associated inflammation, supported mainly by innate immune cells, contributes to tumor growth. Initial innate activation triggers secretion of inflammatory, regenerative, and anti-inflammatory cytokines, which in turn shape the adaptive immune response to the tumor. Here, we review the current understanding of the intricate dialog between cancer-associated inflammation and anti-tumor immunity. We discuss the changing nature of these interactions during tumor progression and the impact of the tissue environment on the anti-tumor immune response. In this context, we outline important gaps in current understanding by considering basic research and findings in the clinic. The future of cancer immunotherapy and its utility depend on improved understanding of these interactions and the ability to manipulate them in a predictable and beneficial manner.

中文翻译：

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Pas de Deux：通过癌症相关的炎症控制抗肿瘤免疫力。

在许多情况下，与肿瘤相关的炎症主要由先天免疫细胞支持，有助于肿瘤的生长。最初的先天激活触发炎症，再生和抗炎细胞因子的分泌，进而形成对肿瘤的适应性免疫反应。在这里，我们回顾了当前对癌症相关炎症与抗肿瘤免疫之间复杂对话的理解。我们讨论了在肿瘤进展过程中这些相互作用的变化性质以及组织环境对抗肿瘤免疫反应的影响。在这种情况下，我们通过考虑临床的基础研究和发现来概述当前理解中的重要差距。