BACKGROUND The associations and predictors of the gamut of autoimmune conditions in pemphigus and pemphigoid have been examined in few large-scale controlled studies. OBJECTIVE To examine associations of pemphigus or pemphigoid with autoimmune disorders and related outcomes in adults. METHODS Data from the 2002-2012 National Inpatient Sample were analyzed, including an ∼20% sample of all US hospitalizations (n = 72,108,077 adults). RESULTS In multivariable logistic regression models, pemphigus (adjusted odds ratio 1.46, 95% confidence interval 1.30-1.63) and pemphigoid (adjusted odds ratio 1.35, 95% confidence interval 1.24-1.48) were associated with ≥1 autoimmune disorder. Pemphigus was associated with 9 of 29 and pemphigoid with 13 of 32 autoimmune disorders examined in bivariable models. Among pemphigus inpatients, unspecified autoimmune disease, vitiligo, eosinophilic esophagitis, and myasthenia gravis had the strongest effect sizes. Whereas, among pemphigoid inpatients, unspecified autoimmune disease, vitiligo, and chronic urticaria had the strongest effect sizes. There were significant differences of autoimmune comorbidities by age, sex, and race/ethnicity. The estimated excess annual costs of hospital care attributed to autoimmune disorders among inpatients with pemphigus was $2,286,588 and pemphigoid $4,301,681. LIMITATION Lack of treatment history data. CONCLUSION Inpatients with pemphigus or pemphigoid had increased odds of multiple cutaneous, extracutaneous, and systemic autoimmune disorders, which were associated with a considerable cost burden.

中文翻译：

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天疱疮或天疱疮与美国成人住院患者自身免疫性疾病的关系。

背景技术天疱疮和天疱疮中自身免疫性疾病的范围的关联和预测因子已在少数大规模对照研究中进行了研究。目的探讨天疱疮或天疱疮与成人自身免疫性疾病及相关结局的关系。方法分析了2002-2012年国家住院患者样本中的数据，包括美国所有住院患者中约20％的样本（n = 72,108,077名成人）。结果在多变量logistic回归模型中，天疱疮（调整后的优势比为1.46，95％置信区间为1.30-1.63）和天疱疮（调整后的优势比为1.35，95％置信区间为1.24-1.48）与≥1种自身免疫性疾病相关。在双变量模型中，天疱疮与29例中的9例和天疱疮与32例中的13例自身免疫性疾病相关。在天疱疮住院患者中，未指明的自身免疫性疾病，白癜风，嗜酸性食管炎和重症肌无力的效果最大。而在类天疱疮患者中，未明确的自身免疫性疾病，白癜风和慢性荨麻疹的效果最大。自身免疫合并症在年龄，性别和种族/民族方面存在显着差异。患有天疱疮的患者中因自身免疫性疾病而导致的住院治疗的年度额外费用估计为2,286,588美元，天疱疮为4,301,681美元。局限性缺乏治疗历史记录数据。结论患有天疱疮或类天疱疮的住院患者发生多种皮肤，皮外和全身性自身免疫性疾病的几率增加，这与可观的成本负担相关。在天疱疮患者中，未明确的自身免疫性疾病，白癜风和慢性荨麻疹的影响最大。自身免疫合并症在年龄，性别和种族/民族方面存在显着差异。患有天疱疮的患者中，因自身免疫性疾病而导致的住院治疗的年度额外费用估计为2,286,588美元，天疱疮为4,301,681美元。局限性缺乏治疗历史记录数据。结论患有天疱疮或类天疱疮的住院患者发生多种皮肤，皮外和全身性自身免疫性疾病的几率增加，这与可观的成本负担相关。在天疱疮患者中，未明确的自身免疫性疾病，白癜风和慢性荨麻疹的影响最大。自身免疫合并症在年龄，性别和种族/民族方面存在显着差异。患有天疱疮的患者中因自身免疫性疾病而导致的住院治疗的年度额外费用估计为2,286,588美元，天疱疮为4,301,681美元。局限性缺乏治疗历史记录数据。结论患有天疱疮或类天疱疮的住院患者发生多种皮肤，皮外和全身性自身免疫性疾病的几率增加，这与可观的成本负担相关。患有天疱疮的患者中因自身免疫性疾病而导致的住院治疗的年度额外费用估计为2,286,588美元，天疱疮为4,301,681美元。局限性缺乏治疗历史记录数据。结论患有天疱疮或类天疱疮的住院患者发生多种皮肤，皮外和全身性自身免疫性疾病的几率增加，这与可观的成本负担相关。患有天疱疮的患者中因自身免疫性疾病而导致的住院治疗的年度额外费用估计为2,286,588美元，天疱疮为4,301,681美元。局限性缺乏治疗历史记录数据。结论患有天疱疮或类天疱疮的住院患者发生多种皮肤，皮外和全身性自身免疫性疾病的几率增加，这与可观的成本负担相关。