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Early limbic microstructural alterations in apathy and depression in de novo Parkinson's disease
Movement Disorders ( IF 7.4 ) Pub Date : 2019-07-15 , DOI: 10.1002/mds.27793
Stéphane Prange 1, 2 , Elise Metereau 1, 2 , Audrey Maillet 1 , Eugénie Lhommée 3, 4 , Hélène Klinger 2 , Pierre Pelissier 3, 4 , Danielle Ibarrola 5 , Rolf A Heckemann 6, 7 , Anna Castrioto 3, 4 , Léon Tremblay 1 , Véronique Sgambato 1 , Emmanuel Broussolle 1, 2, 8 , Paul Krack 9 , Stéphane Thobois 1, 2, 8
Affiliation  

Whether structural alterations underpin apathy and depression in de novo parkinsonian patients is unknown. The objectives of this study were to investigate whether apathy and depression in de novo parkinsonian patients are related to structural alterations and how structural abnormalities relate to serotonergic or dopaminergic dysfunction.

中文翻译:

新发帕金森病冷漠和抑郁的早期边缘微结构改变

结构性改变是否支持新发帕金森病患者的冷漠和抑郁尚不清楚。本研究的目的是调查新发帕金森病患者的冷漠和抑郁是否与结构改变有关,以及结构异常如何与血清素或多巴胺能功能障碍相关。
更新日期:2019-07-15
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