PURPOSE To assess macular vasculature in healthy infants and children using OCT angiography (OCTA). DESIGN Prospective cross-sectional study. PARTICIPANTS One hundred thirty-five normal maculae of 89 healthy infants and children (mean age, 8.5±5.3 years; range, 9 weeks-17 years) treated at the Duke University Eye Center. METHODS We imaged 135 maculae of 89 pediatric patients using the standard Spectralis tabletop and investigational Spectralis with Flex module devices, both equipped with investigational OCTA software (Heidelberg Engineering, Heidelberg, Germany). OCT angiography images of the superficial vascular complex (SVC) and deep vascular complex (DVC) were analyzed for foveal avascular zone (FAZ) area and superficial and deep vessel density. We assessed effects of age, gender, race, axial length (AL), and central subfield thickness on FAZ and vessel density. Patients with both eyes imaged were assessed for agreement between the FAZ and vessel densities of the left and right eyes. MAIN OUTCOME MEASURES The FAZ area, as well as vessel area density (VAD) and vessel length density (VLD) in the SVC and DVC. RESULTS The FAZ varied significantly with race; white patients showed a significantly smaller FAZ than black patients (mean difference, 0.11 mm2; P = 0.004). The FAZ did not vary with age, gender, or AL (P > 0.05). In the SVC, VAD and VLD varied significantly with age (P < 0.001) and AL (R2 = 0.46; P < 0.001) but not gender (P > 0.05). The SVC VLD was significantly different between races and ethnicities (P = 0.037), but VAD was not (P < 0.05). In the DVC, VAD and VLD also varied significantly with age (P < 0.001) and AL (R2 = 0.46; P < 0.001) but not gender or race (P > 0.05). There was excellent agreement between the right and left eyes for FAZ (intraclass correlation [ICC], 0.97), SVC VLD (ICC, 1.00), and DVC VLD (ICC, 1.00). CONCLUSIONS Quantitative studies of pediatric perifoveal vasculature should consider age, race, and AL. In eyes with unilateral disease, the perifoveal vasculature in the unaffected eye may be used as a control comparison because there is excellent agreement between eyes.

中文翻译：

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使用OCT血管造影术评估婴儿和儿童的健康眼睛中的黄斑微脉管系统。

目的使用OCT血管造影术（OCTA）评估健康婴儿和儿童的黄斑脉管系统。设计前瞻性横断面研究。参加者在杜克大学眼科中心接受治疗的89例健康婴儿和儿童（平均年龄8.5±5.3岁；范围为9周至17岁）的135个正常黄斑。方法我们使用标准Spectralis桌面和带有Flex模块装置的Spectralis研究性影像对89名儿科患者的135个黄斑进行了成像，这两种装置均配备了研究性OCTA软件（德国海德堡海德堡工程公司（Heidelberg Engineering，Heidelberg，Germany））。分析了浅表血管复合物（SVC）和深层血管复合物（DVC）的OCT血管造影图像的中央凹无血管区域（FAZ）面积以及浅表和深血管密度。我们评估了年龄，性别，种族，轴向长度（AL），中心子场厚度对FAZ和血管密度的影响。对双眼成像的患者评估FAZ与左眼和右眼血管密度之间的一致性。主要观察指标SVC和DVC中的FAZ区域以及血管面积密度（VAD）和血管长度密度（VLD）。结果FAZ随种族的不同而有显着差异。白人患者的FAZ显着小于黑人患者（平均差异为0.11 mm2； P = 0.004）。FAZ没有随年龄，性别或AL的变化而变化（P> 0.05）。在SVC中，VAD和VLD随年龄变化（P <0.001）和AL（R2 = 0.46; P <0.001）显着变化，而性别则无变化（P> 0.05）。SVC VLD在种族和族裔之间有显着差异（P = 0.037），但VAD没有差异（P <0.05）。在DVC中，VAD和VLD也随着年龄而显着变化（P <0。001）和AL（R2 = 0.46； P <0.001），而不是性别或种族（P> 0.05）。FAZ（类内相关性[ICC]，0.97），SVC VLD（ICC，1.00）和DVC VLD（ICC，1.00）在左右眼之间有很好的一致性。结论儿科小凹周围脉管系统的定量研究应考虑年龄，种族和AL。在患有单侧疾病的眼睛中，未受影响的眼睛的中央凹周围脉管系统可以用作对照比较，因为眼睛之间的一致性非常好。