Since 2011, 2% chlorhexidine in 70% isopropyl alcohol (2% chlorhexidine tincture) has been widely used in Korea. To investigate changes in chlorhexidine sensitivity of staphylococci causing central line-associated bloodstream infections, 264 blood culture isolates from adult patients treated in intensive care units of five university hospitals between 2008 and 2016 were analysed. We observed no significant changes in chlorhexidine minimum inhibitory and bactericidal concentrations, or in the prevalence of resistance-associated genes before and after introduction of 2% chlorhexidine tincture. Thus, there was no evidence of increased resistance to chlorhexidine in staphylococci causing central line-associated bloodstream infections.

中文翻译：

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从与中心线相关的血流感染患者中分离出的葡萄球菌对氯己定的敏感性。

自2011年以来，韩国已广泛使用70％异丙醇中的2％洗必泰（2％洗必泰tin剂）。为了调查引起中枢线相关性血流感染的葡萄球菌洗必泰敏感性的变化，分析了2008年至2016年间在五所大学医院的重症监护室接受治疗的成年患者的264株血培养分离株。我们观察到在引入2％洗必泰tin剂之前和之后，洗必泰最低抑菌和杀菌浓度或耐药相关基因的发生率均未见明显变化。因此，没有证据表明葡萄球菌对氯己定的抗药性增加，引起中央线相关的血流感染。