Gold catalysis in the last two decade has witnessed remarkable improvements in terms of efficiency and scope of application in numerous organic reactions. In particular, the unique ability of gold catalysts to activate π-bonds to effect various cycloaddition reactions has received significant attention. However, the catalytic application of gold in creating new opportunities for the regioselective cycloaddition reactions went largely unnoticed. Steric/electronic environment of substrates, ancillary ligand and reaction time seems to be some of the associated regio-directing factors in the gold-catalyzed cycloaddition reactions. Hence, in this review on gold catalyzed regioselective cycloaddition reactions, a complete update about the different types of gold-catalyzed cycloaddition of substrates like alkynes, alkenes, allenes, and ynamides along with the factors governing the selectivity is discussed. Applications towards natural product synthesis and tandem reactions to showcase the synthetic utility of such processes are also highlighted.

在过去的二十年中，金催化在效率和在许多有机反应中的应用范围方面取得了显着改善。特别地，金催化剂活化π键以实现各种环加成反应的独特能力已经引起了极大的关注。但是，金在为区域选择性环加成反应创造新机会方面的催化应用在很大程度上未被注意到。底物的立体/电子环境，辅助配体和反应时间似乎是金催化的环加成反应中一些相关的区域导向因素。因此，在本篇有关金催化的区域选择性环加成反应的综述中，对不同类型的底物（如炔烃，烯烃，丙二烯，并讨论了酰胺类化合物以及控制选择性的因素。还强调了在天然产物合成和串联反应中的应用，以展示此类工艺的合成效用。