Metalloproteins are crucial for life. The mutual relationship between metal ions and proteins makes metalloproteins able to accomplish key processes in biological systems, often very difficult to reproduce with inorganic coordination compounds under mild conditions. Taking inspiration from nature, many efforts have been devoted to developing artificial molecules as metalloprotein mimics. We have witnessed an explosion of protein design strategies leading to designed metalloproteins, ranging from stable structures to functional molecules. This review illustrates the most recent results for inserting metalloprotein functions in designed and engineered protein scaffolds. The selected examples highlight the potential of different approaches for the construction of artificial molecules capable of simulating and even overcoming the features of natural metalloproteins.

中文翻译：

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设计和天然支架中的工程金属蛋白功能。

金属蛋白对生命至关重要。金属离子与蛋白质之间的相互关系使金属蛋白质能够完成生物系统中的关键过程，通常在温和条件下很难用无机配位化合物进行复制。从自然界中汲取灵感，人们已经做出了许多努力来开发作为金属蛋白模拟物的人工分子。我们目睹了蛋白质设计策略的爆炸式增长，导致设计出金属蛋白，从稳定的结构到功能分子。这篇评论阐明了在设计和工程化的蛋白质支架中插入金属蛋白功能的最新结果。