At least, more than half of our understanding of extracellular vesicles owes to the studies conducted over the past few years. When it became clear that the exosomes have various potentials in medicine, extensive research has focused on these potentials in a variety of areas including cancer, drug delivery and regenerative medicine. The growing understanding of molecular structure and functions of exosomes causes the vision to become brighter in the exosomes complexity, and our attitude toward these vesicles has undergone changes accordingly. Proteomic and transcriptomic studies on exosomes have highlighted their molecular diversity. In this review, we explicitly examine the exosomes composition, molecular structure and their therapeutic potentials in some diseases. Due to the very heterogeneous nature of exosomes, the process of their use as a therapeutic agent in the clinic has been challenged. We are still at the beginning of recognizing the molecular composition of exosomes and mechanisms that affect their physiology and biology. The growing trend of engineering of exosomes has shown a promising future to further utilize them in a different field. Molecular profiling of exosomes and their content for their related potentials in regenerative medicine should be done exactly for further defining a minimum content for specific therapeutic potentials.

中文翻译：

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间充质干细胞衍生的外泌体分子含量与其潜能之间的关系：为以外泌体为基础的治疗方法开辟道路。

至少，我们对细胞外囊泡的理解的一半以上归功于过去几年进行的研究。当外泌体在医学上具有多种潜能时，广泛的研究就集中在包括癌症，药物输送和再生医学在内的各个领域的这些潜能上。对外泌体分子结构和功能的日益了解使外泌体复杂性的视野变得更加明亮，因此我们对这些囊泡的态度也发生了变化。关于外泌体的蛋白质组学和转录组学研究突出了它们的分子多样性。在这篇综述中，我们明确检查了外泌体的组成，分子结构及其在某些疾病中的治疗潜力。由于外来体的性质非常不同，在临床上将其用作治疗剂的过程受到了挑战。我们仍在认识外泌体的分子组成以及影响其生理和生物学的机制。外泌体工程学的增长趋势显示了在不同领域进一步利用它们的有希望的未来。外泌体的分子谱分析及其在再生医学中的相关潜力含量应准确进行，以进一步确定特定治疗潜力的最低含量。