A crucial stage of the Streptomyces life cycle is the sporulation septation, a process were dozens of cross walls are synchronously formed in the aerial hyphae in a highly coordinated manner. This process includes the remodeling of the spore envelopes to make Streptomyces spores resistant to detrimental environmental conditions. Sporulation septation and the synthesis of the thickened spore envelope in S. coelicolor A3(2) involves the Streptomyces spore wall synthesizing complex SSSC. The SSSC is a multi-protein complex including proteins directing peptidoglycan synthesis (MreBCD, PBP2, Sfr, RodZ) and cell wall glycopolymer synthesis (PdtA). It also includes two eukaryotic like serin/threonine protein kinases (eSTPK), PkaI and PkaH, which were shown to phosphorylate MreC. Since unbalancing phosphorylation activity by either deleting eSTPK genes or by expressing a second copy of an eSTPK gene affected proper sporulation, a model was developed, in which the activity of the SSSC is controlled by protein phosphorylation.

链霉菌生命周期的一个关键阶段是孢子分离，在此过程中，气生菌丝以高度协调的方式同步形成数十个横壁。该过程包括孢子包膜的重塑以使链霉菌的孢子对有害的环境条件具有抵抗力。孢子形成septation和在增稠孢子包络线的合成天蓝色链霉菌A3（2）包括将链霉菌孢子壁合成复杂的SSSC。SSSC是一种多蛋白复合物，包括指导肽聚糖合成的蛋白（MreBCD，PBP2，Sfr，RodZ）和细胞壁糖聚合物合成（PdtA）。它还包括两个真核样丝氨酸/苏氨酸蛋白激酶（eSTPK），PkaI和PkaH，它们被证明可以磷酸化MreC。由于通过删除eSTPK基因或表达eSTPK基因的第二个拷贝来失去平衡的磷酸化活性影响了适当的孢子形成，因此建立了一个模型，其中SSSC的活性受蛋白质磷酸化的控制。