BDJ Open ( IF 2.5 ) Pub Date : 2019-07-11 , DOI: 10.1038/s41405-019-0021-0 Mithra N Hegde 1 , Priya Gatti 2 , Nidarsh D Hegde 3
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Introduction
Irradiation is known to cause oxidation process among the tissue-altering the properties of teeth leading to tissue necrosis and caries formation. Hence protection of the oral cavity is a major concern to deal with therapy side effects.
Aim
Evaluation of wear resistance property of Enamel against electron beam radiation and analysing the radio protective effects of natural organic compounds.
Materials and methods
Total of 36 healthy extracted human molar teeth were collected, four samples were used as control, and remaining 32 were divided into four groups (N = 8 each): radiation control group and three groups treated with organic compounds during radiation treatment. The enamel samples were tested for FTIR spectroscopy, XRD analysis, SEM and EDAX analysis before and after 70 Gy radiation treatment.
Results and discussion
The particle size of radiation control samples had increased showing decrease in its crystallinity index. Calcium to Phosphorous ratio had also decreased along with structural changes as observed by SEM analysis. But groups treated with organic compounds has maintained tooth integrity in comparable to control groups after radiation treatment.
Conclusion
Virgin coconut oil, vitamin E oil and curcumin has potential radioprotective action against radiation in protecting tissue properties. Hence, with further advanced research, these natural substances should emerge as a topical applicator during radiotherapy to oral cancer patients.
中文翻译：
电子束辐照对搪瓷耐磨性能的保护
介绍
众所周知，辐照会在组织中引起氧化过程，从而改变牙齿的特性，导致组织坏死和龋齿形成。因此，口腔保护是处理治疗副作用的主要问题。
目标
搪瓷对电子束辐射的耐磨性能评估和天然有机化合物的辐射防护效果分析。
材料和方法
共收集36颗健康拔除的人臼齿，4个样本作为对照，其余32颗分为四组（每组N = 8）：放射对照组和放射治疗期间用有机化合物处理的三组。在 70 Gy 辐射处理前后对牙釉质样品进行 FTIR 光谱、XRD 分析、SEM 和 EDAX 分析测试。
结果与讨论
辐射控制样品的粒径增加，表明其结晶度指数降低。通过 SEM 分析观察到，钙磷比也随着结构变化而降低。但与放射治疗后的对照组相比，用有机化合物治疗的组保持了牙齿的完整性。
结论
初榨椰子油、维生素 E 油和姜黄素在保护组织特性方面具有潜在的辐射防护作用。因此，随着更深入的研究，这些天然物质应成为口腔癌患者放射治疗期间的局部涂药器。
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