PURPOSE To compare serum vitamin D levels and patterns of ultraviolet light and dietary exposure among patients with active and inactive noninfectious uveitis and population controls. DESIGN Prospective case-control study. All participants (n = 151) underwent serum 25-hydroxy vitamin D measurement and completed a questionnaire on vitamin D intake and ultraviolet light exposure. Serum 25-hydroxy vitamin D levels were compared between active and inactive uveitis groups and with local population estimates. PARTICIPANTS Adult patients with active and inactive noninfectious uveitis were recruited from 2 Victorian tertiary hospitals and 1 private ophthalmic practice. METHODS Serum 25-hydroxy vitamin D levels were compared between patients with active and inactive uveitis and population-based estimates of serum 25-hydroxy vitamin D levels, stratified by geographic region and season. Vitamin D intakes and exposures based on questionnaire results, including vitamin D supplementation and sunlight exposures on weekdays and weekends, were compared between active and inactive uveitis groups. MAIN OUTCOME MEASURES Serum vitamin D levels, intake of vitamin D, and exposure to sources of vitamin D. RESULTS The median level of serum vitamin D in those with active uveitis (n = 74) was 46 nmol/l (interquartile range [IQR], 29-70 nmol/l), significantly lower than in the inactive control group (n = 77) at 64 nmol/l (IQR, 52-79 nmol/l; P < 0.001). The active uveitis group also showed lower median serum vitamin D levels than the local population median of 62 nmol/l (IQR, 46-77 nmol/l). Vitamin D supplementation also was associated significantly with uveitis inactivity (P = 0.026, Kendall's τ test). In a subanalysis of vitamin D-deficient participants, sun exposure was associated significantly with uveitis inactivity (P = 0.014 for weekday and weekend analyses). CONCLUSIONS Participants with active uveitis showed significantly lower serum 25-hydroxy vitamin D levels than inactive uveitis patients and local population-based estimates. Vitamin D supplementation was found to be associated with decreased uveitis activity, as was sun exposure in those with vitamin D deficiency. These results suggest that vitamin D supplementation should be studied as an option for the prevention of uveitis relapse in at-risk patients.

中文翻译：

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活动性和非活动性非感染性葡萄膜炎患者的维生素D水平和暴露方式。

目的比较活动性和非活动性非感染性葡萄膜炎患者和患者的血清维生素D水平和紫外线照射模式以及饮食暴露情况。设计前瞻性病例对照研究。所有参与者（n = 151）均接受了血清25-羟基维生素D的测量，并完成了有关维生素D摄入量和紫外线暴露的问卷调查。比较活动性和非活动性葡萄膜炎组与当地人群的血清25-羟基维生素D水平。参与者从2所维多利亚州的三级医院和1所私人眼科诊所招募患有活动性和非活动性非感染性葡萄膜炎的成年患者。方法比较活动性和非活动性葡萄膜炎患者的血清25-羟基维生素D水平，以及基于人群的血清25-羟基维生素D水平估计值，按地理区域和季节分层。在活动和非活动性葡萄膜炎组之间比较了基于问卷调查结果的维生素D摄入量和暴露量，包括在工作日和周末补充维生素D和阳光照射。主要观察指标活动性葡萄膜炎患者（n = 74）的血清维生素D水平，摄取的维生素D和暴露于维生素D的来源。结果血清维生素D的中位数水平为46 nmol / l（四分位数范围[IQR]） （29-70nmol / l），显着低于非活动对照组（n = 77）的64nmol / l（IQR，52-79nmol / l； P <0.001）。活动性葡萄膜炎组的血清维生素D水平也低于当地人群的中位数62 nmol / l（IQR，46-77 nmol / l）。补充维生素D也与葡萄膜炎无活动性显着相关（P = 0.026，Kendall' sτ检验）。在缺乏维生素D的参与者的亚分析中，日晒与葡萄膜炎的无活动性显着相关（工作日和周末分析，P = 0.014）。结论活动性葡萄膜炎参与者的血清25-羟基维生素D水平显着低于非活动性葡萄膜炎患者和当地人群的估计值。发现补充维生素D与葡萄膜炎活性降低有关，维生素D缺乏者与日光照射也一样。这些结果表明，应研究补充维生素D作为预防高危患者葡萄膜炎复发的一种选择。结论活动性葡萄膜炎参与者的血清25-羟基维生素D水平显着低于非活动性葡萄膜炎患者和当地人群的估计值。发现补充维生素D与葡萄膜炎活性降低有关，维生素D缺乏者与日光照射也一样。这些结果表明，应研究补充维生素D作为预防高危患者葡萄膜炎复发的一种选择。结论活动性葡萄膜炎参与者的血清25-羟基维生素D水平显着低于非活动性葡萄膜炎患者和当地人群的估计值。发现补充维生素D与葡萄膜炎活性降低有关，维生素D缺乏者与日光照射也一样。这些结果表明，应研究补充维生素D作为预防高危患者葡萄膜炎复发的一种选择。