A broad body of evidence supports both pathogenic and neuroprotective roles for inflammation in amyotrophic lateral sclerosis (ALS)1 but trials of several immunomodulatory drugs have not yielded a beneficial effect in an increasingly complex disorder with multiple upstream cellular causes.2 There has been interest in proteins involved in the microglial response as potential biomarkers for well over a decade.3 4 Recently this has focused on a group of three chitinase proteins, thought to be macrophage-derived, identified in proteomic analysis of cerebrospinal fluid (CSF) taken from ALS patients.5 6 Chitinases have also been studied the pathologically related disorder frontotemporal dementia (FTD).7 8 Although chitin is not produced by mammals, it is suggested that chitinases might act on N -acetylglucosamine-containing extracellular matrix polymers, such as hyaluronan or keratan sulfate, …

中文翻译：

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在肌萎缩性侧索硬化症中解开神经炎症。

大量的证据支持肌萎缩性侧索硬化症（ALS）1中炎症的病原性和神经保护作用，但对几种免疫调节药物的试验并未对越来越复杂的，具有多种上游细胞病因的疾病产生有益的作用。2参与小胶质细胞反应的蛋白质已成为潜在的生物标志物，已有十多年的历史了。34最近，该研究集中在一组三种几丁质酶蛋白质上，这些蛋白质被认为是巨噬细胞衍生的，在从ALS患者中提取的脑脊液（CSF）进行蛋白质组学分析时被鉴定出.5 6还研究了几丁质酶与病理相关的额颞叶痴呆（FTD）。78尽管几丁质不是哺乳动物产生的，但几丁质酶可能作用于含N-乙酰氨基葡糖的细胞外基质聚合物，例如透明质酸或硫酸角质素，…