RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes, including splicing, cleavage and polyadenylation, transport, translation and degradation of coding RNAs, non-coding RNAs and microRNAs. Recent studies indicate that RBPs not only play an instrumental role in normal cellular processes but have also emerged as major players in the development and spread of cancer. Herein, we review the current knowledge about RNA binding proteins and their role in tumorigenesis as well as the potential to target RBPs for cancer therapeutics.

中文翻译：

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癌症 'RBP'eutics-RNA 结合蛋白作为癌症的治疗靶标。

RNA 结合蛋白 (RBP) 在调节各种 RNA 过程中发挥着关键作用，包括编码 RNA、非编码 RNA 和 microRNA 的剪接、切割和多聚腺苷酸化、转运、翻译和降解。最近的研究表明，RBP 不仅在正常细胞过程中发挥重要作用，而且还成为癌症发展和扩散的主要参与者。在此，我们回顾了目前关于 RNA 结合蛋白及其在肿瘤发生中的作用以及靶向 RBP 用于癌症治疗的潜力的知识。