BACKGROUND There are limited data on electrocardiogram (ECG) characteristics and their association with psychotropic drugs in schizophrenia. METHODS Using a cross-sectional design, we included Danish primary care patients with first-time digital ECGs from 2001 to 2015. Patients diagnosed with schizophrenia before ECG recording were matched 1:5 on age, sex, and ECG recording year to controls without psychiatric disease. Multivariable logistic regression was used to compute odds ratios (ORs) with 95% confidence intervals (CIs). RESULTS We included 4486 patients with schizophrenia matched with 22 430 controls (median age, 47 years; male, 55%). Between groups, the prevalence of abnormal ECGs was similar (54%, P = .536), but patients with schizophrenia demonstrated higher median heart rate (79 vs 69 beats per minute, P < .001) and Fridericia-corrected QT (QTc) interval (416 vs 412 ms, P < .001) than controls. QTc prolongation was also more prevalent among patients with schizophrenia (3.4% vs 1.1%, P < .001), and so were pathological Q waves (5.3% vs 3.9%, P < .001). Patients with schizophrenia less frequently demonstrated left ventricular hypertrophy (6.1% vs 9.6%, P < .001) and atrial fibrillation or flutter (0.7% vs 1.4%, P < .001). Among patients with schizophrenia only, particularly antipsychotics were associated with abnormal ECGs (OR, 1.20; 95% CI, 1.04-1.39). CONCLUSIONS Patients with schizophrenia demonstrate a different cardiovascular risk profile than matched controls without psychiatric disease, with higher prevalence of elevated heart rate, QTc prolongation, and pathological Q waves, and lower prevalence of left ventricular hypertrophy and atrial fibrillation or flutter. Particularly antipsychotics were associated with abnormal ECGs. This underscores an integrated care approach when ECG abnormalities are detected in this group.

中文翻译：

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精神分裂症患者的心电图特征及其与精神药物的关联。

背景技术关于精神分裂症中的心电图（ECG）特征及其与精神药物的关联的数据有限。方法：采用横断面设计，我们纳入了2001年至2015年首次使用数字心电图的丹麦基层医疗患者。在心电图记录前被诊断为精神分裂症的患者在年龄，性别和心电图记录年中与非精神病患者的对照年龄比为1：5疾病。多变量逻辑回归用于计算具有95％置信区间（CI）的比值比（OR）。结果我们纳入了4486例精神分裂症患者和22 430名对照者（中位年龄47岁；男性55％）。在各组之间，异常心电图的患病率相似（54％，P = .536），但精神分裂症患者的中位心率较高（每分钟心搏79拍69拍，P <。001）和经Fridericia校正的QT（QTc）间隔（416 vs 412 ms，P <.001）。QTc延长在精神分裂症患者中也更为普遍（3.4％比1.1％，P <.001），病理性Q波也是如此（5.3％比3.9％，P <.001）。精神分裂症患者较少出现左心室肥大（6.1％vs.9.6％，P <.001）和房颤或扑动（0.7％vs 1.4％，P <.001）。仅在精神分裂症患者中，特别是抗精神病药与异常的心电图有关（OR，1.20； 95％CI，1.04-1.39）。结论精神分裂症患者表现出的心血管疾病风险与无精神疾病的对照者不同，心律升高，QTc延长和病理性Q波的患病率更高，左心室肥大和心房纤颤或扑动的患病率较低。特别是抗精神病药与异常的心电图有关。当在该组中检测到ECG异常时，这突出了一种综合护理方法。