Abstract

2-[(5-Amino-1H-pyrrol-2-yl)sulfanyl]acetic acid esters have been synthesized in up to 77% yield by the one-pot reaction of lithiated propargylamines with isothiocyanates followed by sequential treatment with t-BuOK–DMSO and alkyl 2-bromoacetates. The process occurs through the initial formation of the thiophene core, followed by its recyclization into the pyrrole nucleus at a higher temperature (ca. 45–60 °C).

2-[(5-Amino-1H-pyrrol-2-yl)sulfanyl]acetic acid esters have been synthesized in up to 77% yield by the one-pot reaction of lithiated propargylamines with isothiocyanates followed by sequential treatment with t-BuOK–DMSO and alkyl 2-bromoacetates. The process occurs through the initial formation of the thiophene core, followed by its recyclization into the pyrrole nucleus at a higher temperature (ca. 45–60 °C).

中文翻译：

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2-[（5-氨基-1H-吡咯-2-基）硫烷基]乙酸酯的合成：由炔丙基胺，异硫氰酸酯和2-溴乙酸烷基酯组成的一锅组件

抽象的

通过锂化炔丙基胺与异硫氰酸酯的一锅反应，然后用t- BuOK顺序处理，合成了2-[（5-氨基-1 H-吡咯-2-基）硫烷基]乙酸酯，产率高达77％。–DMSO和2-溴乙酸烷基酯。该过程通过噻吩核的初步形成，然后在更高的温度（约45–60°C）下将其再循环到吡咯核中而发生。

通过锂化炔丙基胺与异硫氰酸酯的一锅反应，然后用t- BuOK顺序处理，合成了2-[（5-氨基-1 H-吡咯-2-基）硫烷基]乙酸酯，产率高达77％。–DMSO和2-溴乙酸烷基酯。该过程通过噻吩核的初步形成，然后在更高的温度（约45–60°C）下将其再循环到吡咯核中而发生。