The genetic approach, based on the study of inherited forms of deafness, has proven to be particularly effective for deciphering the molecular mechanisms underlying the development of the peripheral auditory system, the cochlea and its afferent auditory neurons, and how this system extracts the physical parameters of sound. Although this genetic dissection has provided little information about the central auditory system, scattered data suggest that some genes may have a critical role in both the peripheral and central auditory systems. Here, we review the genes controlling the development and function of the peripheral and central auditory systems, focusing on those with demonstrated intrinsic roles in both systems and highlighting the current underappreciation of these genes. Their encoded products are diverse, from transcription factors to ion channels, as are their roles in the central auditory system, mostly evaluated in brainstem nuclei. We examine the ontogenetic and evolutionary mechanisms that may underlie their expression at different sites.

中文翻译：

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涉及外周和中央听觉系统的发育和生理的基因。

遗传学方法基于对耳聋遗传形式的研究，已被证明对于破译周围听觉系统，耳蜗及其传入听觉神经元发育的分子机制以及该系统如何提取物理参数特别有效。的声音。尽管这种遗传解剖很少提供有关中央听觉系统的信息，但分散的数据表明某些基因可能在周围和中央听觉系统中都起着关键作用。在这里，我们审查控制外围和中央听觉系统的发育和功能的基因，重点放在那些在两个系统中都表现出内在作用的基因，并着重说明这些基因当前的不足。他们编码的产品多种多样，从转录因子到离子通道，以及它们在中央听觉系统中的作用，主要在脑干核中进行评估。我们研究了可能在不同位点表达的基础的本体和进化机制。