Maturation of neuronal circuits requires selective elimination of synaptic connections. Although neuron-intrinsic mechanisms are important in this process, it is increasingly recognized that glial cells also play a critical role. Without proper functioning of these cells, the number, morphology, and function of synaptic contacts are profoundly altered, resulting in abnormal connectivity and behavioral abnormalities. In addition to their role in synaptic refinement, glial cells have also been implicated in pathological synapse loss and dysfunction following injury or nervous system degeneration in adults. Although mechanisms regulating glia-mediated synaptic elimination are still being uncovered, it is clear this complex process involves many cues that promote and inhibit the removal of specific synaptic connections. Gaining a greater understanding of these signals and the contribution of different cell types will not only provide insight into this critical biological event but also be instrumental in advancing knowledge of brain development and neural disease.

中文翻译：

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消除突触的神经胶质信号传导。

神经元回路的成熟需要选择性消除突触连接。尽管神经元内在机制在此过程中很重要，但人们日益认识到，神经胶质细胞也起着至关重要的作用。没有这些细胞的正常功能，突触接触的数量，形态和功能会发生深刻变化，从而导致异常的连通性和行为异常。除了它们在突触细化中的作用外，神经胶质细胞还与成人损伤或神经系统变性后的病理性突触丧失和功能障碍有关。尽管仍未发现调节神经胶质介导的突触消除的机制，但很明显，这个复杂的过程涉及促进和抑制特定突触连接去除的许多线索。