BACKGROUND The association between the extremely low-frequency magnetic field generated by overhead power lines and neurodegenerative disease is still a matter of debate. METHODS A population-based case-control study was carried out on the residents in the Milan metropolitan area between 2011 and 2016 to evaluate the possible association between exposure to extremely low-frequency magnetic fields generated by high-voltage overhead power lines and Alzheimer's dementia and Parkinson's disease. A statistical analysis was performed on cases and controls matched by sex, year of birth and municipality of residence (with a case to controls ratio of 1 : 4) using conditional logistic regression models adjusted for socio-economic deprivation and distance from the major road network as potential confounders. RESULTS Odds ratios for residents <50 m from the source of exposure compared with residents at ≥600 m turned out to be 1.11 (95% confidence interval: 0.95-1.30) for Alzheimer's dementia and 1.09 (95% confidence interval: 0.92-1.30) for Parkinson's disease. CONCLUSIONS The finding of a weak association between exposure to the extremely low-frequency magnetic field and neurodegenerative diseases suggests the continuation of research on this topic. Moreover, the low consistency between the results of the already existing studies emphasises the importance of increasingly refined study designs.

中文翻译：

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距高压架空电力线的居住距离以及阿尔茨海默氏痴呆症和帕金森氏病的风险：意大利北部都市区基于人群的病例对照研究。

背景技术由架空电力线产生的极低频磁场与神经退行性疾病之间的关联仍是争论的问题。方法在2011年至2016年之间对米兰市区的居民进行了基于人群的病例对照研究，以评估高压架空电力线产生的极低频磁场与阿尔茨海默氏症和痴呆症之间的可能联系。帕金森氏病。使用根据社会经济剥夺和与主要道路网的距离进行了调整的条件逻辑回归模型，对与性别，出生年份和居住城市（病例与对照组的比例为1：4）匹配的病例和对照进行了统计分析。作为潜在的混杂因素。结果居民的赔率< 距暴露源50 m处的居民与≥600 m处的居民相比，阿尔茨海默氏痴呆的患病率分别为1.11（95％置信区间：0.95-1.30）和帕金森氏病为1.09（95％置信区间：0.92-1.30）。结论在极低频磁场中暴露与神经退行性疾病之间存在弱关联的发现表明该主题的研究仍在继续。此外，现有研究结果之间的一致性较低，这突出了日益完善的研究设计的重要性。结论在极低频磁场中暴露与神经退行性疾病之间存在弱关联的发现表明该主题的研究仍在继续。此外，现有研究结果之间的一致性较低，这突出了日益完善的研究设计的重要性。结论在极低频磁场中暴露与神经退行性疾病之间存在弱关联的发现表明该主题的研究仍在继续。此外，现有研究结果之间的一致性较低，这突出了日益完善的研究设计的重要性。