Restoring gene flow into small, isolated populations can alleviate genetic load and decrease extinction risk (i.e., genetic rescue), yet gene flow is rarely augmented as a conservation strategy. Due to this discrepancy between opportunity and action, a recent call was made for widespread genetic rescue attempts. However, several aspects of augmenting gene flow are poorly understood, including the magnitude and duration of beneficial effects and when deleterious effects are likely to occur. We discuss the remaining uncertainties of genetic rescue in order to promote and direct future research and to hasten progress toward implementing this potentially powerful conservation strategy on a broader scale.

中文翻译：

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基因拯救的令人兴奋的潜力和不确定性。

将基因流恢复到孤立的小种群中可以减轻遗传负荷并降低灭绝风险（即遗传拯救），但是作为保护策略，很少增加基因流。由于机会与行动之间的差异，最近呼吁进行广泛的基因拯救尝试。但是，人们对增强基因流的几个方面知之甚少，包括有益作用的程度和持续时间以及何时可能发生有害作用。我们讨论了基因拯救的剩余不确定性，以促进和指导未来的研究，并加快在更广泛的范围内实施这一潜在强大的保护策略的进展。