Non-lethal growth inhibition by arresting the starch utilization system of clinically relevant human isolates of Bacteroides dorei.,RSC Medicinal Chemistry

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Non-lethal growth inhibition by arresting the starch utilization system of clinically relevant human isolates of Bacteroides dorei.
RSC Medicinal Chemistry ( IF 4.1 ) Pub Date : 2019-07-05 , DOI: 10.1039/c9md00301k
Anthony D Santilli ₁ , Jordan T Russell ₂ , Eric W Triplett ₂ , Kristi J Whitehead ₃ , Daniel C Whitehead ₁

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We describe the inhibition of the starch utilization system (Sus) belonging to various strains of Bacteroides dorei in a non-lethal manner using the small molecule probe, acarbose. Concentrations of acarbose as low as 5 μM significantly impede the growth of B. dorei and increase the doubling time of cultures. The successful inhibition of this species of Bacteroides is relevant to several disease states including type I diabetes mellitus. This method continues to explore a new, potential route to intervene in illnesses associated with aberrant changes in the composition of the human gut microbiota through the strategic manipulation of its constituents.

中文翻译：

通过阻止临床相关的人类拟杆菌（Bacteroides dorei）的淀粉利用系统来阻止非致命性生长。

我们使用小分子探针，阿卡波糖，以非致死的方式描述了对属于各种拟杆菌的菌株的淀粉利用系统（Sus）的抑制作用。低至5μM的阿卡波糖浓度会显着阻碍dorei。B. dorei的生长，并增加培养的倍增时间。该种拟杆菌属的成功抑制与包括I型糖尿病在内的几种疾病有关。这种方法继续探索一种新的，可能的途径，即通过对其成分的战略性操纵来干预与人类肠道菌群组成异常变化有关的疾病。

更新日期：2019-07-05

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