Expression of miRNAs is critical for the regulation of several cell functions including proliferation, migration, differentiation, and survival, as well as extracellular matrix (ECM) remodeling. The dynamic interplay between miRNAs, ECM macromolecules, and the tumor microenvironment plays critical roles in many aspects of human diseases such as metabolic disorders and cancers. Circulating and secreted miRNAs, via membrane vesicles, affect cell-cell communication and cellular metabolic pathways, underscoring their significance in tumor progression. The primary goal of this article is to highlight the importance of epigenetic regulatory factors, focusing on miRNA-mediated ECM reorganization and their functional relationships, and how matrix-mediated miRNAs affect tumor progression.

中文翻译：

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miRNA与细胞外基质之间的动态相互作用会影响肿瘤的微环境。

miRNA的表达对于调节几种细胞功能（包括增殖，迁移，分化和存活以及细胞外基质（ECM）重塑）至关重要。miRNA，ECM大分子和肿瘤微环境之间的动态相互作用在人类疾病的许多方面（例如代谢紊乱和癌症）起着至关重要的作用。循环和分泌的miRNA通过膜囊泡影响细胞间的通讯和细胞代谢途径，从而强调了它们在肿瘤进展中的重要性。本文的主要目的是强调表观遗传调控因子的重要性，重点是miRNA介导的ECM重组及其功能关系，以及基质介导的miRNA如何影响肿瘤进展。