Candidalysin is a cytolytic peptide toxin secreted by the invasive form of the human pathogenic fungus, Candida albicans. Candidalysin is critical for mucosal and systemic infections and is a key driver of host cell activation, neutrophil recruitment and Type 17 immunity. Candidalysin is regarded as the first true classical virulence factor of C. albicans but also triggers protective immune responses. This review will discuss how candidalysin was discovered, the mechanisms by which this peptide toxin contributes to C. albicans infections, and how its discovery has advanced our understanding of fungal pathogenesis and disease.

中文翻译：

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念珠菌溶素：在白色念珠菌感染中的发现和作用。

念珠菌溶素是一种细胞溶解肽毒素，由侵入性的人类致病性真菌白色念珠菌分泌。念珠菌溶血素对黏膜和全身感染至关重要，是宿主细胞活化、中性粒细胞募集和 17 型免疫的关键驱动因素。Candidalysin 被认为是第一个真正的白色念珠菌经典毒力因子，但也引发保护性免疫反应。这篇综述将讨论念珠菌溶素是如何被发现的，这种肽毒素导致白色念珠菌感染的机制，以及它的发现如何促进了我们对真菌发病机制和疾病的理解。