Although historically research has focused on transcription as the central governor of protein expression, protein translation is now increasingly being recognized as a major factor for determining protein levels within cells. The central nervous system relies on efficient updating of the protein landscape. Thus, coordinated regulation of mRNA localization, initiation, or termination of translation is essential for proper brain function. In particular, dendritic protein synthesis plays a key role in synaptic plasticity underlying learning and memory as well as cognitive processes. Increasing evidence suggests that impaired mRNA translation is a common feature found in numerous psychiatric disorders. In this review, we describe how malfunction of translation contributes to development of psychiatric diseases, including schizophrenia, major depression, bipolar disorder, and addiction.

中文翻译：

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蛋白质翻译和精神病。

尽管历史上的研究集中于转录作为蛋白质表达的主要调控因素，但蛋白质翻译现在已被越来越多地视为确定细胞内蛋白质水平的主要因素。中枢神经系统依赖于蛋白质结构的有效更新。因此，协调的mRNA定位，翻译的起始或终止对正常的大脑功能至关重要。尤其是，树突状蛋白的合成在学习和记忆以及认知过程中的突触可塑性中起关键作用。越来越多的证据表明，受损的mRNA翻译是许多精神疾病中常见的特征。在这篇评论中，我们描述了翻译失误如何导致包括精神分裂症在内的精神疾病的发展，