BACKGROUND Respiratory syncytial virus (RSV) is an important virus found in adult hospitalized patients. OBJECTIVES To study the clinical outcomes of hospitalized patients aged ≥ 15 years and diagnosed with RSV infection. STUDY DESIGN Both retrospective and prospective cohort studies were conducted at a university hospital between May 2014 and December 2015. RESULTS RSV was detected in 86 of 1562(5.5%) adult hospitalized patients suspected of respiratory viral infection. Sixty-nine patients were included in the study. RSV was detected by RT-PCR (82.6%), IFA (10.1%), and both RT-PCR and IFA (7.3%). Most patients (87.0%) were aged ≥ 50 years. Cardiovascular diseases, pulmonary diseases, immunocompromised hosts, and diabetes were the major comorbidities. The common manifestations were cough (92.8%), dyspnea (91.3%), sputum production (87.0%), tachypnea (75.4%), wheezing (73.9%), and fever (71.0%). Fifty- five patients (79.7%) were diagnosed with pneumonia. Hypoxemia (SpO2 ≤ 92%) was found in 53.6% patients. Twenty-five of 69(36.2%) patients developed respiratory failure and required ventilatory support. Cardiovascular complications were found in 24.6% of patients. Congestive heart failure, acute myocardial infarction (MI), new atrial fibrillation, and supraventricular tachycardia were found in 9(13.0%), 7(10.1%), 4(5.8%), and 3(4.3%) of 69 patients, respectively. Overall mortality was 15.9%. Pneumonia (81.8%) and acute MI (18.2%) were the major causes of death. CONCLUSIONS Most adult hospitalized patients with RSV infection were of advanced age and had comorbidities. Cardiopulmonary complications were the major causes of death. Management and prevention of RSV infection in these vulnerable groups are necessary.

中文翻译：

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成人住院患者呼吸道合胞病毒感染的临床表现和结局。

背景技术呼吸道合胞病毒（RSV）是在成年住院患者中发现的重要病毒。目的研究≥15岁住院并诊断为RSV感染的患者的临床结局。研究设计2014年5月至2015年12月期间在大学医院进行了回顾性和前瞻性队列研究。结果在1562名（5.5％）疑似呼吸道病毒感染的成人住院患者中检测到RSV。该研究包括69名患者。通过RT-PCR（82.6％），IFA（10.1％）以及RT-PCR和IFA（7.3％）检测到RSV。大多数患者（87.0％）年龄≥50岁。心血管疾病，肺部疾病，免疫功能低下的宿主和糖尿病是主要合并症。常见表现为咳嗽（92.8％），呼吸困难（91.3％），痰液产生（87.0％），呼吸急促（75.4％），喘息（73.9％）和发烧（71.0％）。有55名患者（79.7％）被诊断出患有肺炎。在53.6％的患者中发现了低氧血症（SpO2≤92％）。69名患者中有25名（36.2％）出现呼吸衰竭并需要通气支持。24.6％的患者发现了心血管并发症。在69例患者中，分别有9例（13.0％），7例（10.1％），4例（5.8％）和3例（4.3％）发现有充血性心力衰竭，急性心肌梗死（MI），新房颤和室上性心动过速。 。总死亡率为15.9％。肺炎（81.8％）和急性心肌梗死（18.2％）是主要的死亡原因。结论大多数成人RSV感染住院患者均为高龄患者，并有合并症。心肺并发症是主要的死亡原因。