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Interactive and Multifactorial Mechanisms of Calcific Vascular and Valvular Disease
Trends in Endocrinology & Metabolism ( IF 11.4 ) Pub Date : 2019-09-01 , DOI: 10.1016/j.tem.2019.06.001 Linda L Demer 1 , Yin Tintut 2
Trends in Endocrinology & Metabolism ( IF 11.4 ) Pub Date : 2019-09-01 , DOI: 10.1016/j.tem.2019.06.001 Linda L Demer 1 , Yin Tintut 2
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Calcific vascular and valvular disease (CVVD) is widespread and has major health consequences. Although coronary artery calcification has long been associated with hyperlipidemia and increased mortality, recent evidence suggests that its progression is increased in association with cholesterol-lowering HMG-CoA reductase inhibitors ('statins') and long-term, high-intensity exercise. A nationwide trial showed no cardiovascular benefit of vitamin D supplements. Controversy remains as to whether calcium deposits in plaque promote or prevent plaque rupture. CVVD appears to occur through mechanisms similar to those of intramembranous, endochondral, and osteophytic skeletal bone formation. New evidence implicates autotaxin, endothelial-mesenchymal transformation, and microRNA and long non-coding RNA (lncRNA) as novel regulatory factors. New therapeutic options are being developed.
中文翻译：
钙化性血管和瓣膜病的相互作用和多因素机制
钙化性血管和瓣膜病 (CVVD) 很普遍，对健康有重大影响。尽管长期以来冠状动脉钙化与高脂血症和死亡率增加有关，但最近的证据表明，其进展与降低胆固醇的 HMG-CoA 还原酶抑制剂（“他汀类药物”）和长期高强度运动有关。一项全国性试验表明，维生素 D 补充剂对心血管没有益处。关于斑块中的钙沉积是促进还是阻止斑块破裂仍存在争议。CVVD 似乎通过类似于膜内、软骨内和骨赘骨骼形成的机制发生。新证据表明自分泌运动因子、内皮间充质转化、微小 RNA 和长链非编码 RNA (lncRNA) 是新的调控因子。
更新日期：2019-09-01
中文翻译：
钙化性血管和瓣膜病的相互作用和多因素机制
钙化性血管和瓣膜病 (CVVD) 很普遍，对健康有重大影响。尽管长期以来冠状动脉钙化与高脂血症和死亡率增加有关，但最近的证据表明，其进展与降低胆固醇的 HMG-CoA 还原酶抑制剂（“他汀类药物”）和长期高强度运动有关。一项全国性试验表明，维生素 D 补充剂对心血管没有益处。关于斑块中的钙沉积是促进还是阻止斑块破裂仍存在争议。CVVD 似乎通过类似于膜内、软骨内和骨赘骨骼形成的机制发生。新证据表明自分泌运动因子、内皮间充质转化、微小 RNA 和长链非编码 RNA (lncRNA) 是新的调控因子。
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